2018
DOI: 10.1111/ijd.14066
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Disseminated tuberculosis following adalimumab treatment in psoriasis despite negative screening

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Cited by 7 publications
(8 citation statements)
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“…There are case reports of active TB development during adalimumab therapy, despite negative screening for active and latent TB before the treatment. 9 In our case report, before the second cycle of adalimumab the patient received rifampicin one month before the therapy due to the positive IGRA test, although the chest X-ray showed no deviation from the norm. Before the first cycle the above tests were negative.…”
Section: Discussionmentioning
confidence: 64%
See 1 more Smart Citation
“…There are case reports of active TB development during adalimumab therapy, despite negative screening for active and latent TB before the treatment. 9 In our case report, before the second cycle of adalimumab the patient received rifampicin one month before the therapy due to the positive IGRA test, although the chest X-ray showed no deviation from the norm. Before the first cycle the above tests were negative.…”
Section: Discussionmentioning
confidence: 64%
“…Atypical forms of the disease might cause a delay in the correct diagnosis. 9,10 In addition, it was also found that infliximab and adalimumab suppress IFN-γ production, significantly inhibiting T cell activation and reducing CD4 + by up to 70% for infliximab and 50% for adalimumab. Such effect was not described for etanercept.…”
Section: Discussionmentioning
confidence: 95%
“…PPD positive represented the previous infection but could be affected by other factors. Some elderly, weak, or immunosuppressive patients may have a false negative result . Inoculation with Bacillus Calmette‐Gu Rin (BCG) can produce a false positive result; however, BCG is usually inoculated in childhood and its influence diminishes with time .…”
Section: Acknowledgmentsmentioning
confidence: 99%
“…1,2 Anti-tumor necrosis factor alpha (anti-TNF-α) may lead patients to be more susceptible to mycobacterial infections and, in particular, to tuberculosis (TB) reactivation. 3 Herein, we report a psoriasis patient under adalimumab therapy that developed M. kansasii infection with skin manifestations. To our knowledge, this is the first report of this association.…”
Section: Introductionmentioning
confidence: 97%
“…Anti-tumor necrosis factor alpha (anti- TNF-α) may lead patients to be more susceptible to mycobacterial infections and particularly to tuberculosis (TB) reactivation. 3 …”
Section: Introductionmentioning
confidence: 99%