Disseminated tumor cells in the blood of patients with gastric cancer are an independent predictive marker of poor prognosis

Abstract

Detection of DTC in venous blood of gastric cancer patients is an independent predictive marker of poor prognosis and thus could help to define patients for adjuvant therapy with this tumor entity.

Detection of circulating tumour cells in gastric and hepatocellular carcinoma: A systematic review

“…In most of the studies included in this current analysis, the CTC detection rate was related to the surgical manoeuvres during the surgical removal of excisable cancers, which in turn was initially correlated with poor survival. 18,22 Surgery-related CTC release was also shown in another study, even though postoperative CTC positivity was associated with an improved prognosis. 41 Using the CELLSEARCH Õ system, the CTC detection rate varied between 14% and 55% in 14 nonmetastatic and 27 metastatic patients, respectively (!2 CTCs/ 7.5 ml).…”

“…3,6,16,22 It has not been possible to assess their relative importance and clinical significance because the data available are currently so limited. Most of the studies published in the literature reported positive results (i.e.…”

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] However, it is of note that no clear conclusion could be drawn from these heterogeneous studies, which were often underpowered. Among the several molecular markers tested (e.g.…”

“…[13][14][15][16][17][18][19] The CTC detection rate was related to the surgical manoeuvres during the surgical removal of excisable cancers, and was initially correlated with poor survival. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Some reports have also focused on the patient's blood stored for autologous transfusion during surgery by testing CTCs using various techniques after removal from blood and undergoing freezing, filtering and irradiation. 19 …”

Clinical studies monitoring circulating and disseminated tumor cells in gastrointestinal cancers

“…The presence of CTCs in circulation suggests not only a high risk of tumor recurrence, but also an unfavorable clinical outcome even in the early stages of GC [20]. The prognostic impact of CTCs in GC has been reported in several studies [21][22][23][24][25][26][27]. The sensitivity of RT-PCR CTC detection was superior to the other less commonly used cytological detection methods involving fluorescence-activated cell sorting (FACS), immunohistochemistry (IHC), and immunocytochemistry (ICC) [20].…”