Disseminated Tumor Embolism From Breast Cancer Leading to Multiorgan Failure

Tsoi, Daphne; Rowsell, Corwyn; McGregor, Caitlin; Kelly, Catherine M.; Verma, Sunil; Pritchard, Kathleen I.

doi:10.1200/jco.2009.25.1009

Cited by 15 publications

(10 citation statements)

References 15 publications

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“…PECAM1 expression by IL30-treated cancer cells might select for cancer clusters that easily engage endothelial cells in encircling vasculogenesis (47). PECAM1 mediates tumor cell-tumor cell homotypic adhesion as well as tumor cell-platelet-endothelial cell interactions (48), which can shape intravascular tumor cell aggregates within IL30-treated tumors and prepare for cancer cell dissemination (49).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-30 Promotes Breast Cancer Growth and Progression

et al. 2016

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The inflammatory tissue microenvironment that promotes the development of breast cancer is not fully understood. Here we report a role for elevated IL30 in supporting the breast cancer cell viability and invasive migration. IL30 was absent in normal mammary ducts, ductules, and acini of histologically normal breast and scanty in the few stromal infiltrating leukocytes. In contrast, IL30 was expressed frequently in breast cancer specimens where it was associated with triple-negative and HER2 þ molecular subtypes. In stromal leukocytes found in primary tumors or tumor-draining lymph nodes, which included mainly CD14 þ monocytes, CD68 þ macrophages, and

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Section: Discussionmentioning

confidence: 99%

Interleukin-30 Promotes Breast Cancer Growth and Progression

et al. 2016

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“…Intravascular tumor microemboli, representing multicellular epithelial tumor cells, are often detected as an incidental finding during autopsy of cancer patients [56]. The most common malignancies associated with development of tumor emboli are mucin-secreting adenocarcinomas originating in the breast, colon, lung, or stomach, as well as hepatocellular carcinoma, prostate cancer, choriocarcinoma, and renal cell carcinoma [57][58][59].…”

Section: Studies Of Ctc Clusters In Circulationmentioning

confidence: 99%

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition

et al. 2015

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“…IBC is characterized by invasion into dermal lymphatic vessels where IBC cells form tumor emboli (Van Laere et al, 2006). Spreading of tumor emboli within lymphatic and blood vessels leads to distant metastasis and multi-organ failure in IBC patients (Tsoi et al, 2010). Dissemination of carcinoma cells can be regulated by cues from the inflammatory cells within the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties

Mohamed

El-Ghonaimy

Nouh

et al. 2014

The International Journal of Biochemistry & Cell Biology

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Although there is a growing literature describing the role of macrophages in breast cancer, the role of macrophages in inflammatory breast cancer (IBC) is unclear. The aim of present study was to isolate and characterize tumor associated macrophages of IBC and non-IBC patients and define their role in IBC. Tumor infiltrating monocytes/macrophages (CD14+ and CD68+) were measured by immunohistochem-istry using specific monoclonal antibodies. Blood drained from axillary vein tributaries was collected during breast cancer surgery and the percentage of CD14+ in the total isolated leukocytes was assessed by flow cytometric analysis. CD14+ cells were separated from total leukocytes by immuno-magnetic beads technique and were cultured overnight. Media conditioned by CD14+ were collected and subjected to cytokine profiling using cytokine antibody array. Wound healing and invasion assays were used to test whether cytokines highly secreted by tumor drained macrophages induce motility and invasion of breast cancer cells. We found that macrophages highly infiltrate into carcinoma tissues of IBC patients. In addition blood collected from axillary tributaries of IBC patients is highly enriched with CD14+ cells as compared to blood collected from non-IBC patients. Cytokine profiling of CD14+ cells isolated from IBC patients revealed a significant increase in secretion of tumor necrosis factor-α; monocyte chemoat-tractant protein-1/CC-chemokine ligand 2; interleukin-8 and interleukin-10 as compared to CD14+ cells isolated from non-IBC patients. Tumor necrosis factor-a, interleukin-8 and interleukin-10 significantly increased motility and invasion of IBC cells in vitro. In conclusion, macrophages isolated from the tumor microenvironment of IBC patients secrete chemotactic cytokines that may augment dissemination and metastasis of IBC carcinoma cells.

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Disseminated Tumor Embolism From Breast Cancer Leading to Multiorgan Failure

Cited by 15 publications

References 15 publications

Interleukin-30 Promotes Breast Cancer Growth and Progression

Interleukin-30 Promotes Breast Cancer Growth and Progression

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition

Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties

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