2019
DOI: 10.1016/j.plasmid.2019.102446
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Dissemination of blaKPC-2 in an NTEKPC by an IncX5 plasmid

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Cited by 15 publications
(16 citation statements)
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“…We further analysed the genetic environment of the resistance genes. We found that the genetic environment around bla KPC−2 , bla SHV−106 , bla CTX−M−15 , bla OXA−1 , and bla TEM−1B are identical in ST15, upstream, and downstream of bla KPC−2 are IS Kpn27 and IS Kpn6 , suggesting that the resistance genes may be transmitted via plasmids [ 41 ]. We found that the ST15 CRKP isolates formed three subgroups when we performed a phylogenetic analysis, implying that there may be clonal transmission between them.…”
Section: Discussionmentioning
confidence: 99%
“…We further analysed the genetic environment of the resistance genes. We found that the genetic environment around bla KPC−2 , bla SHV−106 , bla CTX−M−15 , bla OXA−1 , and bla TEM−1B are identical in ST15, upstream, and downstream of bla KPC−2 are IS Kpn27 and IS Kpn6 , suggesting that the resistance genes may be transmitted via plasmids [ 41 ]. We found that the ST15 CRKP isolates formed three subgroups when we performed a phylogenetic analysis, implying that there may be clonal transmission between them.…”
Section: Discussionmentioning
confidence: 99%
“…Tn4401 is also commonly inserted within other transposon or insertion sequences generating multidrug resistance transposable elements [337,338]. It is worth noting that although unusual, bla KPC genes are found associated to non-Tn4401 genetic environments [339][340][341]. A search at the National Center for Biotechnology Information Pathogen Detection Browser (https://www.ncbi.nlm.nih.gov/pathogens) found 47 variants of KPC and 8716 records.…”
Section: Carbapenemases In a Baumannii: Kpc β-Lactamasesmentioning
confidence: 99%
“…O mecanismo neste caso é muito similar ao descrito para A. baumannii. Nestas linhagens resistentes há a adição de 4-amino-arabinose no LPS, de novo causando repulsão a polimixina B 119 . Neste caso pode-se observar que a linhagem sensível à polimixina B apresenta uma CIM mais baixa que as linhagens resistentes, indicando que este mecanismo de resistência pode afetar o modo de ação do Pep20.…”
Section: Plantaricina 149unclassified
“…107 Em quase todas as linhagens testadas foi possível observar sinergismo, com exceção de AMKP4 e AMKP10, que como já discutido anteriormente, possuem mecanismo de adição de 4-amino-arabinose, que diminui a carga negativa do LPS e consequentemente dificulta a interação de antimicrobianos positivamente carregados. 119 Isso mais uma vez mostra que realmente Pep20 interage com a membrana externa neste mecanismo de sinergismo.…”
Section: Plantaricina 149unclassified
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