Dissemination of carbapenemase-producing Enterobacterales through wastewater and gulls at a wastewater treatment plant in Sweden

Woksepp, Hanna; Karlsson, Klara; Börjesson, Stefan; Lindsjö, Oskar Karlsson; Söderlund, Robert; Bonnedahl, Jonas

doi:10.1016/j.scitotenv.2023.163997

Cited by 6 publications

(1 citation statement)

References 78 publications

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“…The presence of clinically relevant multidrug-resistant (MDR) bacteria in the environment is a growing concern, with wildlife, particularly wild birds, being viewed as important sentinels for AMR surveillance 5 , 6 . Although wild birds can acquire antimicrobial-resistant bacteria/genes, likely from foraging in anthropogenically impacted areas including both landfills and WWTPs 7 – 9 , the role of wild birds in the dissemination of clinically relevant AMR needs further investigation 10 . Several studies have suggested that wild birds could be competent vectors of AMR and potentially disperse AMR through their movements 8 , 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan

Mansoor,

Lu,

Woksepp

et al. 2024

Sci Rep

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The emergence of plasmid-mediated tigecycline resistance gene tet(X4) among clinically relevant bacteria has promoted significant concerns, as tigecycline is considered a last-resort drug against serious infections caused by multidrug-resistant bacteria. We herein focused on the isolation and molecular characterization of tet(X4)-positive Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. coli) in wild bird populations with anthropogenic interaction in Faisalabad, Pakistan. A total of 150 birds including black kites (Milvus migrans) and house crows (Corvus splendens) were screened for the presence of tigecycline resistance K. pneumoniae and E. coli. We found two K. pneumoniae and one E. coli isolate carrying tet(X4) originating from black kites. A combination of short- and long-read sequencing strategies showed that tet(X4) was located on a broad host range IncFII plasmid family in K. pneumoniae isolates whereas on an IncFII-IncFIB hybrid plasmid in E. coli. We also found an integrative and conjugative element ICEKp2 in K. pneumoniae isolate KP8336. We demonstrate the first description of tet(X4) gene in the WHO critical-priority pathogen K. pneumoniae among wild birds. The convergence of tet(X4) and virulence associated ICEKp2 in a wild bird with known anthropogenic contact should be further investigated to evaluate the potential epidemiological implications. The potential risk of global transmission of tet(X4)-positive K. pneumoniae and E. coli warrant comprehensive evaluation and emphasizes the need for effective mitigation strategies to reduce anthropogenic-driven dissemination of AMR in the environment.

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Section: Introductionmentioning

confidence: 99%

Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan

Mansoor,

Lu,

Woksepp

et al. 2024

Sci Rep

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Dirty habits: potential for spread of antibiotic-resistance by black-headed gulls from waste-water treatment plants

Martín-Vélez,

Navarro,

Vazquez

et al. 2024

Environ Sci Pollut Res

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Anthropogenic environments such as wastewater treatment plants (WWTPs) and landfills are sources of antimicrobial resistance (AMR). Black-headed gulls (Chroicocephalus ridibundus) frequently use WWTPs and may be vectors for AMR. We used GPS tracking data for 39 gulls for up to 8 months, combined with a shedding curve, to study sources and dispersal distances of AMR in Iberia. The gulls used 21 different WWTPs (684 visits) and three landfills (21 visits). Areas of high risk of AMR dissemination were an average of 25 km from the infection source, with a maximum of 500 km. Solar saltworks and natural waterbodies were particularly exposed to AMR dissemination, followed by agriculture, sports facilities, and tourist beaches. There was important variability between individual gulls in their habitat specialization, and which WWTPs they visited. Studying the spatial movements of gulls after visiting WWTPs and landfills helps pinpoint sensitive locations where pathogen transmission is most likely.

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Antimicrobial resistance among clinically significant bacteria in wildlife: An overlooked one health concern

Li,

Mowlaboccus,

Jackson

et al. 2024

International Journal of Antimicrobial Agents

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Dissemination of carbapenemase-producing Enterobacterales through wastewater and gulls at a wastewater treatment plant in Sweden

Cited by 6 publications

References 78 publications

Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan

Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan

Dirty habits: potential for spread of antibiotic-resistance by black-headed gulls from waste-water treatment plants

Antimicrobial resistance among clinically significant bacteria in wildlife: An overlooked one health concern

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