Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic spreading in ovarian cancer model

Féki, Anis; Berardi, Philip; Bellingan, Geoff; Major, A. L.; Krause, Karl‐Heinz; Petignat, Patrick; Zehra, Rubab; Pervaiz, Shazib; Irminger-Finger, Irmgard

doi:10.1016/j.critrevonc.2008.12.003

Cited by 49 publications

(42 citation statements)

References 31 publications

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“…In any case, it is found, in agreement with experiments, see Figure 1, that single cell invasion is more conservative [34], while the invasion of tumor spheroids causes the disruption of the mesothelium, see Figure 2, with the appearance of tumor foci which infiltrate the peritoneum and potentially seed metastatic tumor growth [10,37].…”

Section: Introductionsupporting

confidence: 71%

Individual Cell-Based Model for In-Vitro Mesothelial Invasion of Ovarian Cancer

Giverso

Scianna

Preziosi

et al. 2010

Math. Model. Nat. Phenom.

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Abstract. In vitro transmesothelial migration assays of ovarian cancer cells, isolated or aggregated in multicellular spheroids, are reproduced deducing suitable Cellular Potts Models (CPM). We show that the simulations are in good agreement with the experimental evidence and that the overall process is regulated by the activity of matrix metalloproteinases (MMPs) and by the interplay of the adhesive properties of the cells with the extracellular matrix and between cells, both of the same type and of different types. In particular, the process depends on the ability of the cell to induce the loosening of cadherin-mediated junctions. Coherently with experiments, it is found that single cell invasion is more conservative with a crucial role played by MMPs. A similar important role is played in cell spheroid invasion, which in comparison is more disruptive. It achieves monofocal or multifocal characteristics according to the relative adhesion affinity among cells or between them and the mesothelial layer.

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Section: Introductionsupporting

confidence: 71%

Individual Cell-Based Model for In-Vitro Mesothelial Invasion of Ovarian Cancer

Giverso

Scianna

Preziosi

et al. 2010

Math. Model. Nat. Phenom.

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“…Instead, cancer cells move with the peritoneal fluid to distant sites by physical forces, such as fluid hydrodynamics and gravity (Carmignani et al, 2003). In the absence of ascites, cancer cells are restricted in their motion and implant near to the primary site (Feki et al, 2009).…”

mentioning

confidence: 99%

Primary Ovarian Rhabdomyosarcoma in a Dog

Boeloni

Reis

Nascimento

et al. 2012

Journal of Comparative Pathology

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“…1 Epithelial ovarian cancer is often accompanied by severe ascites and peritoneal spreading. However, the mechanism of peritoneal seeding, spreading, and progression is still poorly understood.…”

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confidence: 99%