Dissemination of Polymyxin B Sensitivity in El Tor &lt;i&gt;Vibrio cholerae&lt;/i&gt; O1 Strains in Odisha, India

Pal, Bibhuti Bhusan; Behera, Dipti Ranjan; Nayak, Smruti Ranjan; Nayak, Ashish Kumar; Biswal, Bhagyalaxmi

doi:10.7883/yoken.jjid.2020.592

Cited by 2 publications

(2 citation statements)

References 10 publications

(3 reference statements)

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“…[ 42 ] 44 0 44 Sevagram Asia Outbreak O1_strain El_tor Pal et al. [ 43 ] 1200 127 1073 India Asia Outbreak O1_O139_strain El_tor Iwanaga et al. [ 44 ] 99 11 88 Japan Asia Outbreak O1_strain El_tor Budiman et al.…”

Section: Results Of Studymentioning

confidence: 99%

Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae: A meta-analysis

Igere,

Onohuean,

Iwu

et al. 2023

Infectious Medicine

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Section: Results Of Studymentioning

confidence: 99%

Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae: A meta-analysis

Igere,

Onohuean,

Iwu

et al. 2023

Infectious Medicine

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“…260 clinical strains of VC O1 from 12 states in India tested for Polymixin B susceptibility using Kirby-Bauer disc diffusion method and Polymixin B plate susceptibility assay revealed 88.85% strains were sensitive (36). Another study conducted using 1200 VC O1 isolates collected from 1995-2019 revealed that sensitivity of VC O1 El Tor strains arose in 2005 (37). Additionally, on comparison of recent reports on the antibiotic sensitivity profile of VC strains (24) with that of strains isolated a decade ago (38) it was found that a stark difference in the overall antimicrobial resistance profile exists.…”

Section: Introductionmentioning

confidence: 99%

Mobile Genetic Elements of Vibrio cholerae and the Evolution of Its Antimicrobial Resistance

2021

Front. Trop. Dis

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Vibrio cholerae (VC) is the causative agent of the severe dehydrating diarrheal disease cholera. The primary treatment for cholera is oral rehydration therapy (ORT). However, in case of moderate to severe dehydration, antibiotics are administered to reduce morbidity. Due to the emergence of multidrug resistant (MDR) strains of VC routinely used antibiotics fail to be effective in cholera patients. Antimicrobial resistance (AMR) is encoded in the genome of bacteria and is usually acquired from other organisms cohabiting in the environment or in the gut with which it interacts in the gut or environmental niche. The antimicrobial resistance genes (ARGs) are usually borne on mobile genetic elements (MGEs) like plasmids, transposons, integrons and SXT constin. Horizontal gene transfer (HGT) helps in the exchange of ARGs among bacteria leading to dissemination of AMR. In VC the acquisition and loss of AMR to many antibiotics have been found to be a dynamic process. This review describes the different AMR determinants and mechanisms of resistance that have been discovered in VC. These ARGs borne usually on MGEs have been recovered from isolates associated with past and present epidemics worldwide. These are responsible for resistance of VC to common antibiotics and are periodically lost and gained contributing to its genetic evolution. These resistance markers can be routinely used for AMR surveillance in VC. The review also presents a precise perspective on the importance of the gut microbiome in the emergence of MDR VC and concludes that the gut microbiome is a potential source of molecular markers and networks which can be manipulated for the interception of AMR in the future.

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Dissemination of Polymyxin B Sensitivity in El Tor <i>Vibrio cholerae</i> O1 Strains in Odisha, India

Cited by 2 publications

References 10 publications

Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae: A meta-analysis

Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae: A meta-analysis

Mobile Genetic Elements of Vibrio cholerae and the Evolution of Its Antimicrobial Resistance

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