Introduction:
Mediastinal blastomycosis has been described in multiple case reports, but no review to date has catalogued its various manifestations or response to treatment.
Case presentation:
An otherwise healthy 18‐year‐old female presented with lymphadenopathy and was found to have a large mediastinal mass concerning for lymphoma. A subsequent biopsy revealed Blastomyces dermatitidis; the patient responded well to therapy with amphotericin B and itraconazole. Similar cases are reviewed and analysed.
Conclusion:
Mediastinal blastomycosis is a rare but life‐threatening disease manifestation that responds readily to appropriate antifungal therapy.