2010
DOI: 10.1093/jac/dkq065
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Dissemination of two international linezolid-resistant Staphylococcus epidermidis clones in Greek hospitals

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Cited by 35 publications
(38 citation statements)
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“…We found the C2534T mutation in two alleles of rRNA genes in the 426-3147L strain, as well as several mutations in proteins L3 and L4. The C2534T mutation has been found previously in S. epidermidis where, when it is present in two alleles, as is the case for the 426-3147L isolate, it increased the linezolid MIC to 8 g/ml (48). The mutations found in 426-3147L in genes of proteins L3 and L4 are located close to the position where mutations were identified in other linezolid-resistant staphylococcal isolates (11)(12)(13)(14)28).…”
Section: Discussionsupporting
confidence: 58%
“…We found the C2534T mutation in two alleles of rRNA genes in the 426-3147L strain, as well as several mutations in proteins L3 and L4. The C2534T mutation has been found previously in S. epidermidis where, when it is present in two alleles, as is the case for the 426-3147L isolate, it increased the linezolid MIC to 8 g/ml (48). The mutations found in 426-3147L in genes of proteins L3 and L4 are located close to the position where mutations were identified in other linezolid-resistant staphylococcal isolates (11)(12)(13)(14)28).…”
Section: Discussionsupporting
confidence: 58%
“…1 The LRSE-ST22 isolates have been associated with infection and colonization cases in Spain, France, Germany, and, particularly, Greece, and most of these LRSE-ST22 arise after treatment with linezolid. [1][2][3][4][5][6][7] In this study, we aimed to characterize the first methicillin-and linezolid-resistant S. epidermidis from a patient without previous linezolid exposure in Turkey and to assess its genetic similarity to the close geographical S. epidermidis from Greece.…”
Section: Dissemination Of Staphylococcus Epidermidis St22 With Stablementioning
confidence: 99%
“…In large surveillance studies, the linezolid resistance rates are still low; however, there seems to be a trend toward increased rates (7). S. epidermidis appears to be prone to accumulate linezolid resistance mechanisms, such as mutations in the 23S rRNA and in the ribosomal proteins L3 and L4 (7,10,13,18,19). In addition to alterations in the target site, a more recent linezolid resistance mechanism, the cfr gene, has been increasingly reported in the literature (6,8,30).…”
mentioning
confidence: 99%
“…More recently, an improved multilocus sequence typing (MLST) scheme was developed for S. epidermidis (27), and the method provided additional information related to the population structure and epidemiology of the species (21). Subsequently, several reports have described the epidemiology of nosocomial S. epidermidis, including linezolid-resistant isolates (9,10,13,31,32). However, information regarding the genetic background of S. epidermidis isolates responsible for nosocomial infection within U.S. hospitals remains limited.…”
mentioning
confidence: 99%