Dissipation and safety evaluation of afidopyropen and its metabolite residues in supervised cotton field

Hou, Xiai; Qiao, Tian; Zhao, Yufei; Liu, Dan

doi:10.1016/j.ecoenv.2019.04.089

Cited by 26 publications

(13 citation statements)

References 23 publications

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“…Soaking in water helped the matrices to swell, weakened the interactions of the pesticides with the matrix components and assisted with an efficient extraction 28 . Acetonitrile or water coupled with acetonitrile has emerged as the most versatile extraction solvent for afidopyropen and M440I007 with a high extraction efficiency 4‐7,10 . Therefore, acetonitrile coupled with water is used as the extraction solvent and we further optimized the conditions of soaking water (including water amount and soaking time) based on the recoveries of afidopyropen and its metabolite.…”

Section: Resultsmentioning

confidence: 99%

“…Afidopyropen is prone to metabolize into M440I007 (Fig. 1) in crops, a dimer product of afidopyropen created by cycloaddition at the double bond in the pyrone ring 4‐7 . It is reported that afidopyropen caused rat uterine adenocarcinoma, indicating that there may be a negative impact on animals 8 .…”

Section: Introductionmentioning

confidence: 99%

“…It is reported that afidopyropen caused rat uterine adenocarcinoma, indicating that there may be a negative impact on animals 8 . Therefore, once afidopyropen is sprayed onto crops, residues of afidopyropen and its metabolite M440I007 may be induced in related agricultural products, risking human health 4‐7 . Moreover, the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) assessed that M440I07 was probably hazardous in a similar way to that of its parent because the effects of M440I007 on the myocardium at the high dose were consistent with the parent 9 .…”

Section: Introductionmentioning

confidence: 99%

“…The current methods used for detecting afidopyropen and M440I007 in simple crop and environmental samples, including wheat, fruits, vegetables, cotton and soil, described in the literatures are all QuEChERS pretreatment methods combined with liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) 4‐7,10 . However, there are no available data concerning analytical methods for afidopyropen and M440I007 in other complicated matrices, such as tea.…”

Section: Introductionmentioning

confidence: 99%

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Method validation for detection of afidopyropen and M440I007 in tea

et al. 2023

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BACKGROUND Afidopyropen is a novel biorational insecticide for controlling piercing pests with great potential for application in tea gardens that can form the metabolite M440I007 when utilized for crops. However, because of a lack of analytical method for afidopyropen and M440I007 in tea, there is no means of monitoring the residues. Therefore, method development, validation and simultaneous determination of afidopyropen and M440I007 in fresh tea leaves, dried tea and tea infusion is of prime significance. RESULTS A TPT cartridge‐based method was developed for the solid phase extraction of afidopyropen and M440I007 from tea matrices. Extraction and clean‐up conditions, including the composition, volume and temperature of elutions, were optimized to achieve the best results. Both targets were extracted using water and acetonitrile, with a water:acetonitrile (v/v) ratio of 4:10 for fresh leaves and 8:10 for dried tea, which were then cleaned and analyzed using ultraperformance liquid chromatography‐tandem mass spectrometry. Both analytes demonstrated excellent linearity with a correlation coefficient above 0.998. The optimized analytical method offered limits of quantifications of 0.005, 0.005 and 0.002 mg kg−1 (converted to dried tea) in fresh tea shoots, dried tea and tea infusion for both targets, respectively. Average recoveries of afidopyropen and M440I007 ranged from 79.0% to 101.5%, with relative standard deviations ≤ 14.7%. CONCLUSION The results showed that the method of determination for these insecticides in tea matrices was practical and efficient. © 2023 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Method validation for detection of afidopyropen and M440I007 in tea

et al. 2023

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“…)/ ha, the final residue concentration after 14 days in cottonseed was lower than 0.01 mg/kg and was <0.005−0.0099 mg/kg in soil. 14 Although the residual level of afidopyropen may appear to be relatively small, we cannot ignore the potential pesticide residue risk to other social bees, especially for insecticidesensitive species. So far, data on the residue and sublethal effects of afidopyropen on other social bees except A. mellifera are yet to be observed.…”

Section: ■ Introductionmentioning

confidence: 99%

Evaluation of Afidopyropen Toxicity at Environmentally Relevant Doses to the Asian Honeybee (Apis cerana) Using Physiological and Transcriptome Analysis

Peng

Wang

et al. 2023

J. Agric. Food Chem.

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Afidopyropen is a novel biogenic pesticide widely applied to control sap-feeding pests, and a few studies have evaluated the side effects of afidopyropen on pollinators, excluding the Asian honeybee. Thus, we estimated the physiological influences of afidopyropen in Apis cerana, which could cause significant death and nutritional deficiency in bees after continuous dietary intake (14 days) at the field recommended dose. Moreover, we found afidopyropen ingestion-induced changes in the activity of detoxification enzymes (AChE, GR, CarE) and expression of genes critical for the central nervous system and chemosensory function in the antennae, brain, midgut, and malpighian tubule of exposed bees. However, there was no evidence that there was a long-term impact on foraging activity when observing foragers treated with apfidopyropen as newly emerged workers. Overall, our study provides vital information to improve bee health, which will improve outcomes for beekeepers, increase pollination services, and strengthen pollinator communities.

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