Dissipation behavior, residue distribution and risk assessment of three fungicides in pears

Fang, Qingkui; Wu, Ruifeng; Hu, Guixian; Lai, Aiping; Wu, Kaixin; Zhang, Linwei; Feng, Jiajun; Cao, Haiqun

doi:10.1002/jsfa.10199

Cited by 26 publications

(18 citation statements)

References 17 publications

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“…For the safe application of propiconazole, dietary exposure calculation and risk assessment were studied based on the risk quotient (RQ) method. RQ < 100% indicates that the human exposure concentration by consumption of pesticide‐containing food is lower than the predicted effect concentration, representing an acceptable risk to humans, whereas RQ > 100% indicates unacceptable adverse health effects on humans 19–21 …”

Section: Methodsmentioning

confidence: 99%

Study on degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion under field application

Bai

Chen

et al. 2020

J Sci Food Agric

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BACKGROUND Propiconazole is widely used to control fungal diseases in field crops, including celery and onion. The potential risk to the environment and human health has aroused much public concern. Therefore, it is significant to investigate the degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion. RESULTS A sensitive analytical method for determination of propiconazole residue in celery and onion was established and validated through high‐performance liquid chromatography tandem mass spectrometry. The average recovery rate of propiconazole ranged from 85.7% to 101.8%, with a relative standard deviation of 2.1–6.3%. For the dissipation kinetics, the data showed that propiconazole in celery and onion was degraded, with half‐lives of 6.1–6.2 days and 8.7–8.8 days respectively. In the terminal residue experiments, the residues of propiconazole were below 4.66 mg kg−1 in celery after application two or three times and were below 0.029 mg kg−1 in onion after application of three or four times with an interval of 14 days under the designed dosages. The chronic and acute dietary exposure assessments for propiconazole were valued by risk quotient, with all values being lower than 100%. CONCLUSION Propiconazole in celery and onion was rapidly degraded following first‐order kinetics models. The dietary risk of propiconazole through celery or onion was negligible to consumers. The study not only offers a valuable reference for reasonable usage of propiconazole on celery and onion, but also facilitates the establishment of maximum residue limits in China. © 2020 Society of Chemical Industry

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Section: Methodsmentioning

confidence: 99%

Study on degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion under field application

Bai

Chen

et al. 2020

J Sci Food Agric

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“…Although the effect of diffusion capacity on the in vivo antifungal activity of fungicides has never been studied, several reports have confirmed the ability of fungicides to diffuse from the fruit peel to the mesocarp. For example, Fang et al reported that prochloraz, pyraclostrobin and tebuconazole diffused in the pear peel and were detected in the pear mesocarp, with tebuconazole having the lowest residue concentration in the pear pulp among the studied fungicides [ 23 ]. Pyrimethanil, fludioxonil, cyprodinil and kresoxim-methyl were detected in different layers of apple fruit, and the highest concentrations were found in the apple peel [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Peel Diffusion and Antifungal Efficacy of Different Fungicides in Pear Fruit: Structure-Diffusion-Activity Relationships

Zhu

Chen

Wang

et al. 2022

JoF

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Fungal pathogens can invade not only the fruit peel but also the outer part of the fruit mesocarp, limiting the efficacy of fungicides. In this study, the relationships between fungicide structure, diffusion capacity and in vivo efficacy were evaluated for the first time. The diffusion capacity from pear peel to mesocarp of 11 antifungal compounds, including p-aminobenzoic acid, carbendazim, difenoconazole, dipicolinic acid, flusilazole, gentamicin, kojic acid, prochloraz, quinolinic acid, thiophanate methyl and thiram was screened. The obtained results indicated that size and especially polarity were negatively correlated with the diffusion capacity. Although some antifungal compounds, such as prochloraz and carbendazim, were completely degraded after a few days in peel and mesocarp, other compounds, such as p-aminobenzoic acid and kojic acid, showed high stability. When applying the antifungal compounds at the EC50 concentrations, it was observed that the compounds with high diffusion capacity showed higher in vivo antifungal activity against Alternaria alternata than compounds with low diffusion capacity. In contrast, there was no relationship between stability and in vivo efficacy. Collectively, the obtained results indicated that the diffusion capacity plays an important role in the efficacy of fungicides for the control of pear fruit diseases.

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“…When the matrix effect was within 100% (± 20), it was ignored; when it was greater than 120%, it showed enhancement, and when this was less than 80%, it showed inhibition. The calculation formula is as follows (Fang et al, 2019):…”

Section: Discussionmentioning

confidence: 99%

Residue Dissipation, Degradation Dynamics, and Dietary Risk Assessment of Mandipropamid in Ginseng Under Field Application

Hou

Wei

et al. 2022

Preprint

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Mandipropamid, a new fungicide for oomycete disease, has a strong effect on the blight of many crops and has been registered for the treatment of ginseng blight in China. However, no maximum residue limit (MRL) of mandipropamid has been identified for ginseng, and there have been few related studies. We established and verified the analysis method of mandipropamid in ginseng using high-performance liquid chromatography-tandem mass spectrometry. The method has good linearity and accuracy in the range of 0.002–0.5 mg/kg. The average recovery of mandipropamid was 87.4–101.6%, and the standard deviation was 1.1–10.1. The degradation dynamics showed that the half-life of mandipropamid in ginseng plant and soil was 13.8–28.0 and 9.8–27.4 d, respectively. After the recommended dose of mandipropamid was applied once, the residual content of mandipropamid in fresh ginseng, dried ginseng, red ginseng, ginseng plant, and ginseng soil was <0.01–0.185, <0.01–0.265, 0.085–1.544, 0.075–4.800, and <0.01–0.014 mg/kg, respectively. The dietary risk assessment of mandipropamid on ginseng showed that the risk quotient value was far less than 100%, indicating that the recommended dose of mandipropamid does not cause unacceptable risks to humans. Mandipropamid in ginseng plants and soil rapidly degraded following first-order kinetics models. After the recommended dose of mandipropamid was applied once, it did not cause unacceptable risks to humans. This study not only provides a reasonable spray dosage of mandipropamid to ginseng, but also offers a reference for the establishment of MRLs in China.

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Dissipation behavior, residue distribution and risk assessment of three fungicides in pears

Cited by 26 publications

References 17 publications

Study on degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion under field application

Study on degradation behaviour, residue distribution, and dietary risk assessment of propiconazole in celery and onion under field application

Peel Diffusion and Antifungal Efficacy of Different Fungicides in Pear Fruit: Structure-Diffusion-Activity Relationships

Residue Dissipation, Degradation Dynamics, and Dietary Risk Assessment of Mandipropamid in Ginseng Under Field Application

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