Dissociable Effects of Natural Image Structure and Color on LFP and Spiking Activity in the Lateral Prefrontal Cortex and Extrastriate Visual Area V4

Liebe, S; Logothetis, Nikos K.; Rainer, Gregor

doi:10.1523/jneurosci.1791-10.2011

Cited by 11 publications

(7 citation statements)

References 81 publications

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“…The nature of the relationship between spikes and LFPs is a controversial issue that has attracted much interest (Bauer et al, 1995; Henrie and Shapley, 2005; Mukamel et al, 2005; Kreiman et al, 2006; Liu and Newsome, 2006; Nir et al, 2007; Belitski et al, 2008; Gieselmann and Thiele, 2008; Rasch et al, 2008; Katzner et al, 2009; Khawaja et al, 2009; Xing et al, 2009; Eggermont et al, 2011; Hwang and Andersen, 2011; Jia et al, 2011; Liebe et al, 2011; Lindén et al, 2011; Tsui and Pack, 2011; Zanos et al, 2011b; Lashgari et al, 2012). In a typical experimental scenario, a well-understood property of multi-unit activity (MUA) is compared and contrasted with that of the LFP.…”

Section: Introductionmentioning

confidence: 99%

Local field potentials reflect multiple spatial scales in V4

Mineault¹,

Zanos²,

Pack³

2013

Front. Comput. Neurosci.

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Local field potentials (LFP) reflect the properties of neuronal circuits or columns recorded in a volume around a microelectrode (Buzsáki et al., 2012). The extent of this integration volume has been a subject of some debate, with estimates ranging from a few hundred microns (Katzner et al., 2009; Xing et al., 2009) to several millimeters (Kreiman et al., 2006). We estimated receptive fields (RFs) of multi-unit activity (MUA) and LFPs at an intermediate level of visual processing, in area V4 of two macaques. The spatial structure of LFP receptive fields varied greatly as a function of time lag following stimulus onset, with the retinotopy of LFPs matching that of MUAs at a restricted set of time lags. A model-based analysis of the LFPs allowed us to recover two distinct stimulus-triggered components: an MUA-like retinotopic component that originated in a small volume around the microelectrodes (~350 μm), and a second component that was shared across the entire V4 region; this second component had tuning properties unrelated to those of the MUAs. Our results suggest that the LFP reflects neural activity across multiple spatial scales, which both complicates its interpretation and offers new opportunities for investigating the large-scale structure of network processing.

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Section: Introductionmentioning

confidence: 99%

Local field potentials reflect multiple spatial scales in V4

Mineault¹,

Zanos²,

Pack³

2013

Front. Comput. Neurosci.

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“…Although neural activity in V4 has been related to color and shape processing of visual objects [13][14][15][16] and visual attention 17 , neural responses in lPF have been traditionally associated with working memory, that is, the short-term maintenance and manipulation of sensory information in memory tasks 18,19 . More recently, however, an increasing number of studies have found that the neural circuitry underlying short-term retention of sensory information likely entails earlier sensory cortical areas as well 20 .…”

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confidence: 99%

Theta coupling between V4 and prefrontal cortex predicts visual short-term memory performance

et al. 2012

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Every cognitive act entails the participation of multiple brain regions. In visual short-term memory, for example, visual information is initially encoded in sensory brain areas and then communicated to regions that mediate the retention, manipulation and retrieval of information. One prominent hypothesis that addresses the question of how communication between neural ensembles is achieved claims that neuronal oscillations support the timely coordination of neural activity between different brain regions 1,2 . Specifically, neuronal oscillations in the theta frequency band (3-9 Hz) have been suggested to underlie the interaction between neural ensembles during mnemonic processing 3,4 .A line of evidence supporting this hypothesis stems from studies investigating the role of hippocampal theta in memory formation in rodents [5][6][7] . Additional evidence comes from studies measuring surface-based or intracortical electroencephalography (EEG) in human subjects. In these cases, memory performance correlates with an increase in theta power [8][9][10] . Moreover, enhanced theta synchrony between electric potentials recorded from memory-related areas has been observed 11,12 .These findings raise the question of whether theta synchrony measured at the mesoscopic level of LFPs provides a basis for the timely coordination of spiking output between distant cortical areas that have been traditionally associated with the sensory encoding of visual information on the one hand and mnemonic processing on the other. Moreover, is the precision of coordination between these regions associated with changes in memory performance? To answer these questions, we studied neuronal interactions between the extrastriate visual area V4 and the lateral prefrontal cortex (lPF) while monkeys performed a visual memory task.Although neural activity in V4 has been related to color and shape processing of visual objects [13][14][15][16] and visual attention 17 , neural responses in lPF have been traditionally associated with working memory, that is, the short-term maintenance and manipulation of sensory information in memory tasks 18,19 . More recently, however, an increasing number of studies have found that the neural circuitry underlying short-term retention of sensory information likely entails earlier sensory cortical areas as well 20 . In these cases, both prefrontal regions 21 and V4 have been linked to memory-related oscillatory synchrony. Specifically, theta oscillations are enhanced during the delay period of memory tasks in both lPF and V4 (ref. 22), and increased oscillatory theta synchrony is accompanied by a phase-dependent coding of visual stimuli retained in short-term memory 23,24 .We observed enhanced phase locking between local field potentials recorded in V4 and lPF (inter-area LFP phase locking) that occurred in the theta range (~3-9 Hz) during the memory period of a visual short-term memory task. Increased LFP-phase locking was associated with greater locking of spikes to the phase of the theta oscillations in the respective...

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“…It is likely that V4 plays a critical role. V4 is implicated in color vision (Zeki, 1980 ; Wade et al, 2008 ) in both monkey (Zeki, 1983a ; Wild et al, 1985 ; Brewer et al, 2002 ; Conway and Tsao, 2006 ) and human brains (Zeki et al, 1991 ; McKeefry and Zeki, 1997 ; Wade et al, 2008 ; Goddard et al, 2011 ; Liebe et al, 2011 ; Lofar-Sousa et al, 2016 ) and the responses of cells in it can be selective for hues (Zeki, 1980 ; Conway et al, 2007 ; Brouwer and Heeger, 2013 ). As well, an imaging study of activity in cortical areas which correlate with the perception of colored after-images pinpointed V4 (Sakai et al, 1995 ).…”

Section: Discussionmentioning

confidence: 99%

The Constancy of Colored After-Images

Zeki

Cheadle

Pepper

et al. 2017

Front. Hum. Neurosci.

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We undertook psychophysical experiments to determine whether the color of the after-image produced by viewing a colored patch which is part of a complex multi-colored scene depends on the wavelength-energy composition of the light reflected from that patch. Our results show that it does not. The after-image, just like the color itself, depends on the ratio of light of different wavebands reflected from it and its surrounds. Hence, traditional accounts of after-images as being the result of retinal adaptation or the perceptual result of physiological opponency, are inadequate. We propose instead that the color of after-images is generated after colors themselves are generated in the visual brain.

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Dissociable Effects of Natural Image Structure and Color on LFP and Spiking Activity in the Lateral Prefrontal Cortex and Extrastriate Visual Area V4

Cited by 11 publications

References 81 publications

Local field potentials reflect multiple spatial scales in V4

Local field potentials reflect multiple spatial scales in V4

Theta coupling between V4 and prefrontal cortex predicts visual short-term memory performance

The Constancy of Colored After-Images

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