Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder

Pompei, Francesco; Dima, Danai; Rubia, Katya; Kumari, Veena; Frangou, Sophia

doi:10.1016/j.neuroimage.2011.04.055

Cited by 95 publications

(54 citation statements)

References 54 publications

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“…The second set of studies used psychophysiological interaction (PPI) analysis (22)(23)(24)(25)(26)(27)(28). In these studies, one to three "seed" regions were chosen a priori, and clusters of voxels elsewhere were identified in which the correlation between the time courses of the seed and cluster differed significantly by condition.…”

Section: Significancementioning

confidence: 99%

Flexible brain network reconfiguration supporting inhibitory control

Spielberg

Miller

Heller

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

105

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The ability to inhibit distracting stimuli from interfering with goaldirected behavior is crucial for success in most spheres of life. Despite an abundance of studies examining regional brain activation, knowledge of the brain networks involved in inhibitory control remains quite limited. To address this critical gap, we applied graph theory tools to functional magnetic resonance imaging data collected while a large sample of adults (n = 101) performed a color-word Stroop task. Higher demand for inhibitory control was associated with restructuring of the global network into a configuration that was more optimized for specialized processing (functional segregation), more efficient at communicating the output of such processing across the network (functional integration), and more resilient to potential interruption (resilience). In addition, there were regional changes with right inferior frontal sulcus and right anterior insula occupying more central positions as network hubs, and dorsal anterior cingulate cortex becoming more tightly coupled with its regional subnetwork. Given the crucial role of inhibitory control in goal-directed behavior, present findings identifying functional network organization supporting inhibitory control have the potential to provide additional insights into how inhibitory control may break down in a wide variety of individuals with neurological or psychiatric difficulties. T he ability to exert cognitive control to inhibit distracting stimuli from interfering with goal-directed behavior is crucial for success in most spheres of life, including academic, occupational, health, and general well-being (1). However, such control is impaired under certain conditions in both psychologically/neurologically typical individuals [e.g., overeating during stressful periods (2)] and those with pathological conditions [e.g., addiction (3)]. Consequently, understanding the neural circuitry supporting inhibitory aspects of cognitive control has the potential to provide key insights into a wide array of difficulties, ranging from common activities of daily life to psychiatric disorders.Substantial uncertainty remains regarding the neurobiology supporting inhibitory aspects of cognitive control (4), with the majority of recent research focusing on which particular regions of prefrontal cortex (PFC) are important for which specific aspects of inhibitory control. A large body of research has identified a set of brain regions that appear generally crucial for inhibitory control. For example, consistent activation was identified in several critical regions in a recent meta-analysis of studies using the color-word Stroop (5), which is a classic cognitive control probe (6) and which we use in the present study. This task indexes inhibitory control, because an individual must maintain a task set in the face of irrelevant, but prepotent, information that must be inhibited. The meta-analysis revealed a number of regions, including dorsal anterior cingulate cortex (dACC), lateral PFC (e.g., BA 9/44/45/46), insul...

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Section: Significancementioning

confidence: 99%

Flexible brain network reconfiguration supporting inhibitory control

Spielberg

Miller

Heller

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

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“…In addition, abnormal connectivity between prefrontal and limbic/ paralimbic areas has been reported in euthymic patients during a Stroop task (Pompei et al, 2011b). Only one neuroimaging study tested euthymic as well as depressed and manic BD patients while performing a Stroop task (Blumberg et al, 2003), finding both common and differential effects of conflict in distinct ventral prefrontal areas.…”

Section: Introductionmentioning

confidence: 99%

Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: Preliminary findings from a follow-up state-based fMRI study

Rey¹,

Desseilles²,

Favre³

et al. 2014

Psychiatry Research: Neuroimaging

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a b s t r a c tWe used functional magnetic resonance imaging (fMRI) to examine affective control longitudinally in a group of patients with bipolar disorder (BD). Participants comprised 12 BD patients who underwent repeated fMRI scans in euthymic (n ¼ 11), depressed (n ¼9), or hypomanic (n ¼9) states, and were compared with 12 age-matched healthy controls. During fMRI, participants performed an emotional face-word interference task with either low or high attentional demands. Relative to healthy controls, patients showed decreased activation of the cognitive control network normally associated with conflict processing, more severely during hypomania than during depression, but regardless of level of task demand in both cases. During euthymia, a decreased response to conflict was observed only during the high load condition. Additionally, unlike healthy participants, patients exhibited deactivation in several key areas in response to emotion-conflict trials -including the rostral anterior cingulate cortex during euthymia, the hippocampus during depression, and the posterior cingulate cortex during hypomania. Our results indicate that the ability of BD patients to recruit control networks when processing affective conflict, and the abnormal suppression of activity in distinct components of the default mode network, may depend on their current clinical state and attentional demand.

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“…On a descriptive level, connectivity between the ventrolateral prefrontal cortex and the ventral anterior cingulate cortex appeared to be weaker in relatives. Further, connectivity between the ventrolateral prefrontal cortex and the nucleus caudatus appeared weaker in relatives suffering from major depression but not in healthy relatives of bipolar disorder patients, who showed a negative coupling between ventrolateral prefrontal cortex and dorsolateral prefrontal cortex, which was absent in healthy controls and was interpreted as a compensational mechanism [200]. Interestingly, when directing attention away from fearful and happy faces, hyper-activation of the amygdala, the medial prefrontal cortex, and by trend also of the putamen but only during presentation of fearful faces as distractors was also reported in adolescent relatives of bipolar disorder patients [22].…”

Section: Early Emotional Processesmentioning

confidence: 80%

“…However, on a neural level, relatives of bipolar disorder patients displayed reduced activity in the parietal cortex; unaffected relatives also displayed this reduced activity in the nucleus caudate during the Stroop task [15]. In addition, relatives also showed significantly reduced functional connectivity between the ventrolateral prefrontal cortex and the insula compared to healthy controls during the Stroop task [200]. On a descriptive level, connectivity between the ventrolateral prefrontal cortex and the ventral anterior cingulate cortex appeared to be weaker in relatives.…”

Section: Early Emotional Processesmentioning

confidence: 99%