Dissociable Influences of Opiates and Expectations on Pain

Atlas, Lauren Y.; Whittington, Robert A.; Lindquist, Martin A.; Wielgosz, Joseph; Sonty, Nomita; Wager, Tor D.

doi:10.1523/jneurosci.0383-12.2012

Cited by 152 publications

(171 citation statements)

References 60 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…One approach to investigate additive versus interactive effects of drug and placebo is to adopt a balanced placebo design (Rohsenow and Marlatt, 1981), in which the factors expectancy and drug alternate in a 2 Â 2 factorial manner. Employing just such a design, Atlas et al (2012) observed additive rather than interactive effects in conjunction with the influence of positive expectation on remifentanil analgesia. Their results were substantiated by a complementary fMRI study investigating pain-related responses during the open and hidden administration of varying remifentanil dosages, also allowing inferences about potential interactions: no interactive effects of drug and expectation were observed at the neural level.…”

Section: B Additive Versus Interactive Effectsmentioning

confidence: 99%

Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice

Schedlowski¹,

Enck²,

Rief³

et al. 2015

Pharmacol Rev

266

257

View full text Add to dashboard Cite

Section: B Additive Versus Interactive Effectsmentioning

confidence: 99%

Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice

Schedlowski¹,

Enck²,

Rief³

et al. 2015

Pharmacol Rev

266

257

View full text Add to dashboard Cite

“…A recent study suggests that these two components operate independently from each other. Atlas et al (25) conducted a study to directly examine the relationship between expectations and opioid analgesia. They administered the opioid agonist remifentanil to human subjects during experimental thermal pain and manipulated participants' knowledge of drug delivery using an open-hidden design.…”

Section: B Therapeutic Rituals and Drugs: Common Pathways?mentioning

confidence: 99%

Placebo and the New Physiology of the Doctor-Patient Relationship

Benedetti

2013

Physiological Reviews

356

320

View full text Add to dashboard Cite

Modern medicine has progressed in parallel with the advancement of biochemistry, anatomy, and physiology. By using the tools of modern medicine, the physician today can treat and prevent a number of diseases through pharmacology, genetics, and physical interventions. Besides this materia medica, the patient's mind, cognitions, and emotions play a central part as well in any therapeutic outcome, as investigated by disciplines such as psychoneuroendocrinoimmunology. This review describes recent findings that give scientific evidence to the old tenet that patients must be both cured and cared for. In fact, we are today in a good position to investigate complex psychological factors, like placebo effects and the doctor-patient relationship, by using a physiological and neuroscientific approach. These intricate psychological factors can be approached through biochemistry, anatomy, and physiology, thus eliminating the old dichotomy between biology and psychology. This is both a biomedical and a philosophical enterprise that is changing the way we approach and interpret medicine and human biology. In the first case, curing the disease only is not sufficient, and care of the patient is of tantamount importance. In the second case, the philosophical debate about the mind-body interaction can find some important answers in the study of placebo effects. Therefore, maybe paradoxically, the placebo effect and the doctor-patient relationship can be approached by using the same biochemical, cellular and physiological tools of the materia medica, which represents an epochal transition from general concepts such as suggestibility and power of mind to a true physiology of the doctor-patient interaction. I.WHAT I. WHAT IS A PLACEBO RESPONSE? A. Placebos Were Introduced to Validate the Efficacy of Medical TreatmentsAncient physicians have always used bizarre and odd treatments to cure their patients, with scarce, if any, knowledge of anatomy and physiology. As the anatomical and physiological details of both the animal and the human body started emerging, the need of a scientific explanation of many medical treatments became an imperative objective of physicians and the scientific community. An important historical period whereby scientific skepticism emerged about the efficacy of some medical remedies is approximately in the second half of 1700 and involved treatments like mesmerism, perkinism, and homeopathy (178).To take mesmerism as an example, this was introduced in the second half of 1700 by Franz Anton Mesmer, who claimed to have discovered a healing fluid which he called animal magnetism. To assess the very nature and the efficacy of mesmerism in treating many diseases and symptoms, Louis XVI appointed a commission that was headed by Benjamin Franklin. This commission performed what can be considered one of the first blind assessments and sham (placebo) interventions in the history of medicine. Some women were blindfolded and asked where the mesmeric energy was being applied. As reported by the members of the commission th...

show abstract

“…In a recent study (Atlas et al, 2012), a placebo manipulation was combined with a potent opiate, and participants' knowledge of drug delivery was manipulated in an open-hidden design. The opiate produced the most pronounced effects in the ACC, which was strongly associated with pain affect.…”

Section: Anticipation and Proactive Controlmentioning

confidence: 99%

The role of expectancy and proactive control in stress regulation: A neurocognitive framework for regulation expectation

Raedt

Hooley

2016

Clinical Psychology Review

View full text Add to dashboard Cite

When confronted with stressful or emotionally arousing situations, regulatory abilities should allow us to adaptively cope. However, depressed individuals often have a low sense of perceived control and are characterized by a negative expectation bias regarding their ability to deal with future stressful events. Low expectancy concerning the ability to deal with future stressful events may result in less initiation of proactive control, a crucial mechanism of cognitive control reflecting sustained and anticipatory maintenance of goal-relevant information in the dorsolateral prefrontal cortex to optimize cognitive performance. In this theoretical review we integrate a diverse body of literature. We argue that the expectancy of an individual's regulatory abilities prior to the presentation of an arousing event or stressful task will be related to anticipation and proactive up-or down regulation of specific neurocircuits before the actual encounter with the stressful event occurs, in a manner that can be either adaptive or maladaptive. Moreover, we discuss the important role of self-esteem as well as the ability to accept the situation when coping is not possible. Our approach has implications for a broad range of disorders and conditions in which stress regulation plays a role, and can be used to guide the use of recently developed clinical interventions, as well as to fine-tune interventions to facilitate proactive control. Cortex, stress regulation, anticipation, depression, proactive control, coping, self-esteem, When we are confronted with situations or thoughts perceived as unpleasant, aversive or threatening, a series of biological and psychological processes is activated, generating a coordinated response. This so-called stress response is triggered when an individual's well-being or health is threatened. Relational or financial problems, unpredictability, an acute threat, or a challenging situation such as a job interview are examples of stressful situations or stressors that can initiate a stress response. Regulatory abilities, which we call stress regulation, generally allow us to cope with these situations in an adaptive way. However, there are large individual differences in how well people handle life stressors. Indeed, problems with stress regulation are thought to play a central role in the development and clinical course of depression (Hooley, Orley & Teasdale, 1986;Hankin, 2008;Morris, Ciesla & Garber, 2010). It has also been suggested that, over time, depressive episodes can be triggered by progressively milder and milder stressors (Monroe & Harkness, 2005; but see also Anderson et al., 2016). Keywords: Dorsolateral PrefrontalResearch shows the important role of stress regulation in the development of different forms of psychopathology, such as depression, where psychosocial stressors are strongly implicated in the triggering of new episodes (Kendler et al., 2000).Understanding the role of stressors in depression requires consideration of the interaction between biological, cognitive ...

show abstract

Dissociable Influences of Opiates and Expectations on Pain

Cited by 152 publications

References 60 publications

Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice

Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice

Placebo and the New Physiology of the Doctor-Patient Relationship

The role of expectancy and proactive control in stress regulation: A neurocognitive framework for regulation expectation

Contact Info

Product

Resources

About