2021
DOI: 10.1101/2021.01.14.426647
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Dissociable mechanisms of reward learning co-mature during human adolescence as predicted by macaque lesion models

Abstract: Reward-guided learning and decision-making is a fundamental adaptive ability and depends on a number of component processes. We investigate how such component processes mature during human adolescence. Our approach was guided by analyses of the effects of lateral orbitofrontal lesions in macaque monkeys, as this part of the brain shows clear developmental maturation in humans during adolescence. Using matched tasks and analyses in humans (n=388, 11-35yrs), we observe developmental changes in two key learning m… Show more

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