Dissociated large-scale functional connectivity networks of the precuneus in medication-naïve first-episode depression

Peng, Daihui; Liddle, Elizabeth B.; Iwabuchi, Sarina J.; Zhang, Chen; Wu, Zhiguo; Li, Jun; Jiang, Kaida; Xu, Lin; Liddle, Peter F.; Palaniyappan, Lena; Fang, Yiru

doi:10.1016/j.pscychresns.2015.03.003

Cited by 79 publications

(49 citation statements)

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“…Overall, our findings are in line with studies suggesting that changes in the precuneus may play a central role in the pathophysiology of depression [24]. …”

Section: Discussionsupporting

confidence: 92%

Precuneal Thickness and Depression in Parkinson Disease

et al. 2016

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Background: Depression-related gray matter changes in Parkinson disease (PD) patients have been reported, although studies investigating cortical thickness in early-stage disease are lacking. Objective: We aimed to evaluate cortical changes related to depression in early-stage PD patients with an extensive neuropsychological evaluation. Methods: 17 PD patients and 22 healthy controls underwent a 1.5-T brain MR protocol, and voxel-wise differences in cortical thickness among patients with (n = 6) and without (n = 11) depression and controls were evaluated using FreeSurfer software. Results: Cortical thickness was increased in the precuneus bilaterally in PD patients with depression compared to the other groups (number of vertices >100; p < 0.001, uncorrected) with a direct correlation with the Beck Depression Inventory score (p < 0.001, uncorrected). Conclusion: Precuneal cortical thickening is evident in PD patients with mild-moderate depression even in the early stages of the disease. This finding may reflect the early involvement of this region in the development of PD-related depression.

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“…Overall, our findings are in line with studies suggesting that changes in the precuneus may play a central role in the pathophysiology of depression [24]. …”

Section: Discussionsupporting

confidence: 92%

Precuneal Thickness and Depression in Parkinson Disease

et al. 2016

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“…The precuneus has been found to be activated during the viewing of paintings in healthy individuals (Vartanian and Skov, 2014). In addition, it may be part of a functional network associated with depression, as suggested by a study with first-episode depression patients (Peng et al, 2015) and a study of non-clinical depressive symptoms (Wei et al, 2015). With respect to the supramarginal gyrus, resting state studies provide evidence that hyperactivation of this brain region is involved in depression (Wei et al, 2015;Yin et al, 2015).…”

Section: Discussionmentioning

confidence: 98%

Neural activity during object perception in schizophrenia patients is associated with illness duration and affective symptoms

Stephan‐Otto

Siddi

Esteban

et al. 2016

Schizophrenia Research

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Background: Abnormalities in visual processes have been observed in schizophrenia patients and have been associated with alteration of the lateral occipital complex and visual cortex. However, the relationship of these abnormalities with clinical symptomatology is largely unknown. Methods: We investigated the brain activity associated with object perception in schizophrenia. Pictures of common objects were presented to 26 healthy participants (age = 36.9; 11 females) and 20 schizophrenia patients (age = 39.9; 8 females) in an fMRI study. Results: In the healthy sample the presentation of pictures yielded significant activation (p <.001) of the bilateral fusiform gyrus, bilateral lingual gyrus, and bilateral middle occipital gyrus. In patients, the bilateral fusiform gyrus and bilateral lingual gyrus were significantly activated (p <.001), but not so the middle occipital gyrus. However, significant bilateral activation of the middle occipital gyrus (p <.05) was revealed when illness duration was controlled for. Depression was significantly associated with increased activation, and anxiety with decreased activation, of the right middle occipital gyrus and several other brain areas in the patient group. No association with positive or negative symptoms was revealed. Conclusions:Illness duration accounts for the weak activation of the middle occipital gyrus in patients during picture presentation. Affective symptoms, but not positive or negative symptoms, influence the activation of the right middle occipital gyrus and other brain areas.

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“…The MTG is located in the dorsal attention system and is involved in cued attention and working memory. Abnormal RS FC of the precuneus has been found in depressed patients [Peng et al, 2015;Zhu et al, 2012], which was thought to be linked to a significant dissociation between the DMN and relevant sensory, motor, and attention-processing systems. The precuneus has a crucial role in the integration of mental processing, through its role in cognitive control processes such as visual imagery, episodic memory, and self-directed operations [Cavanna and Trimble, 2006].…”

Section: Discussionmentioning

confidence: 99%

Hippocampal‐DMN disconnectivity in MS is related to WM lesions and depression

Rocca

Pravatà

Valsasina

et al. 2015

Human Brain Mapping

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The hippocampus is part of the default-mode network (DMN) and is functionally hit early in multiple sclerosis (MS). Hippocampal and DMN dysfunctions have been associated with depression, both in patients with MS and in major depressive disorders. We hypothesized that white matter lesions may contribute, through a disconnection mechanism, to hippocampal dysfunction. To test this, we assessed the relationship between hippocampal resting-state (RS) functional connectivity (FC) abnormalities with brain T2 lesion volumes and the presence and severity of depression. Structural and RS fMRI images were acquired from 69 patients with cognitively intact MS and 42 matched healthy controls (HC). Depression was quantified using the Montgomery-Asberg Depression Rating Scale. Seed-voxel hippocampal RS FC was assessed. SPM8 was used for between-group comparisons and correlation analysis between RS FC abnormalities with clinical and structural MRI variables. Compared to HC, patients with MS showed a significant atrophy of the whole brain and left hippocampus (P < 0.001), and a distributed pattern of decreased RS FC between the hippocampi and several cortical-subcortical regions, which were mostly located within the DMN. Reduced hippocampal RS FC with regions of the DMN was strongly correlated with higher T2 lesion volume, longer disease duration, and the severity of depression and disability. In patients with cognitively preserved MS, brain focal WM lesions are related to the functional integration of the hippocampus to other brain regions of the DMN, suggesting a disconnection syndrome. Such a disruption of hippocampal RS FC is likely to contribute to the occurrence of depression and to clinical disability.

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Dissociated large-scale functional connectivity networks of the precuneus in medication-naïve first-episode depression

Cited by 79 publications

References 50 publications

Precuneal Thickness and Depression in Parkinson Disease

Precuneal Thickness and Depression in Parkinson Disease

Neural activity during object perception in schizophrenia patients is associated with illness duration and affective symptoms

Hippocampal‐DMN disconnectivity in MS is related to WM lesions and depression

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