Dissociating action inhibition, conflict monitoring and sensory mismatch into independent components of event related potentials in GO/NOGO task

Kropotov, Juri D.; Пономарев, В. А.; Hollup, Stig; Mueller, Andreas

doi:10.1016/j.neuroimage.2011.04.060

Cited by 107 publications

(119 citation statements)

References 46 publications

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“…This effect occurred despite the equivalent frequency of congruent go and no-go trials (RRR and NNN) supporting previous studies suggesting that the P3 is a reliable marker of response inhibition than the N2 (Enriquez-Geppert et al, 2010;Fallgatter & Strik, 1999;Kropotov et al, 2011;Randall & Smith, 2011;Smith et al, 2007). In line with previous research (Fallgatter et al, 1997;Fallgatter & Strik, 1999) the P3 also showed a more frontal topography on No…”

Section: P3 Amplitude and Topographysupporting

confidence: 89%

“…In response inhibition tasks it is larger in amplitude on no-go trials as well as successful stop trials (Enriquez-Geppert et al, 2010;Fallgatter & Strik, 1999;Smith, Johnstone, & Barry, 2007) and has a more frontal topography (termed 'no-go anteriorisation, NGA) (Fallgatter, Brandeis, & Strik, 1997;Fallgatter & Strik, 1999), potentially reflecting activity in pre-SMA and inferior frontal cortex (Huster et al, 2011) or cingulate regions (Fallgatter, Bartsch, & Herrmann, 2002;Strik, Fallgatter, Brandeis, & Pascual-Marqui, 1998). This has led to the suggestion that in the context of action regulation, the P3 is a marker of response inhibition with some authors proposing it as a more reliable marker of response inhibition than the N2 8 (Kropotov, Ponomarev, Hollup, & Mueller, 2011;Meel, 2005;Randall & Smith, 2011;Smith et al, 2007).…”

Section: The P3 Event-related Potentialmentioning

confidence: 99%

“…Further research is needed to establish the neural generators of the frontal P3 in relation to response inhibition, but suggested sources include the pre-SMA (Kropotov et al, 2011) and the cingulate cortex (Fallgatter et al, 2002). These vary depending on the imaging modality, cognitive task and analysis methods employed however (reviewed in (Huster et al, 2011).…”

Section: P3 Amplitude and Topographymentioning

confidence: 99%

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Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition

Groom

Cragg

2015

Brain and Cognition

155

127

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Background: Developing reliable and specific neural markers of cognitive processes is essential to improve understanding of healthy and atypical brain function. Despite extensive research there remains uncertainty as to whether two electrophysiological markers of cognitive control, the N2 and P3, are better conceptualised as markers of response inhibition or response conflict. The present study aimed to directly compare the effects of response inhibition and response conflict on the N2 and P3 event-related potentials, withinsubjects. Method:A novel hybrid go/no-go flanker task was performed by 19 healthy adults aged 18 to 25 years while EEG data were collected. The response congruence of a central target stimulus and 4 flanking stimuli was manipulated between trials to vary the degree of response conflict. Response inhibition was required on a proportion of trials. N2 amplitude was measured at two frontal electrode sites; P3 amplitude was measured at 4 midline electrode sites.Results: N2 amplitude was greater on incongruent than congruent trials but was not enhanced by response inhibition when the stimulus array was congruent. P3 amplitude was greater on trials requiring response inhibition; this effect was more pronounced at frontal electrodes. P3 amplitude was also enhanced on incongruent compared with congruent trials. Discussion:The findings support a role for N2 amplitude as a marker of response conflict and for the frontal shift of the P3 as a marker of response inhibition. This paradigm could be applied to clinical groups to help clarify the precise nature of impaired action control in disorders such as attention deficit/hyperactivity disorders (ADHD).3

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Section: P3 Amplitude and Topographysupporting

confidence: 89%

Section: The P3 Event-related Potentialmentioning

confidence: 99%

Section: P3 Amplitude and Topographymentioning

confidence: 99%

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Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition

Groom

Cragg

2015

Brain and Cognition

155

127

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“…From the neuropsychological perspective, patients with PTSD show dysfunction of cognitive control [16,17,18], which is reflected in the decrease of P300-like ERP components in PTSD patients (for review, see: Johnson et al, 2013 [19]). The cued GO/NOGO task is designed specifically to measure the P300-like components of cognitive control [10,11,12]. In the presented study, the hypothesis was tested whether the P300 components of cognitive control in the cued GO/NOGO task are impaired in the patient after bilateral hand amputation.…”

Section: Discussionmentioning

confidence: 99%

“…To test brain correlates of cognitive control a specific variant of the cued GO/NOGO task was used [11,12]. In this task, images of animal (a) and plant (p) categories served as relevant stimuli.…”

Section: Erp Case Studymentioning

confidence: 99%

Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation – ERP case study

Chrapusta¹,

Kropotov

Pąchalska

2017

Ann Agric Environ Med.

Self Cite

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Introduction. There is a lack in the worldwide literature of reports on the Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in patients after bilateral hand amputation The aim of this study was to test a hypothesis regarding developing Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation with the use of Event Related Potentials (ERPs). On the basis of previous research, the amplitudes of P3 ERP components elicited in the cued GO/NOGO tasks have been chosen as candidates for neuromarkers of PTSD. Case study. A 24-year-old patient had undergone bilateral hand amputation 12 months previously. The patient was repeatedly operated on (he had undergone successful bilateral hand replantation) and despite the severity of the injuries, he recovered. However, the patient complained of flashbacks, anxiety and sleep difficulties. Specialist tests showed the presence of PTSD. The patient participated in the cued GO/NOGO task (Kropotov, 2009) with recording 19-channel EEG. P3 GO and NOGO waves in this task were found to be significantly smaller, in comparison to a group of healthy control subjects of the same age (N=23) taken from the HBI normative database (https://www.hbimed.com/). This observed pattern of ERP waves in the patient corresponds to the pattern found in PTSD patients. Conclusions. ERPs in a GO/NOGO task can be used in the assessment of the functional brain changes induced by chronic PTSD.

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Aggressiveness, inhibitory control, and emotional states: A provocation paradigm

Sebalo,

Bozzay,

Verona

et al. 2024

Aggressive Behavior

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The current study examines the effects of trait aggressiveness, inhibitory control and emotional states on aggressive behavior in a laboratory paradigm. One hundred and fifty‐one adult participants took part (73 men, 71 women, and 7 nondisclosed). Event Related Potentials (ERPs) during a Go/No‐Go task were utilized to capture the extent of inhibitory processing, with a laboratory provocation paradigm used to assess aggression. Contrary to the expectations, negative affective responses to provocation were negatively associated only with short‐lived aggression and only among those with high past aggressiveness. Furthermore, past aggressiveness was related to a continuous increase in laboratory aggressive behavior regardless of the level of inhibitory control (P3 difference amplitude). However, feeling hostile was associated with short‐lived aggressive behavior, only in those with lower levels of inhibitory control. These findings demonstrate the effect of distinct mechanisms on different patterns of aggressive behavior.

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Dissociating action inhibition, conflict monitoring and sensory mismatch into independent components of event related potentials in GO/NOGO task

Cited by 107 publications

References 46 publications

Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition

Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition

Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation – ERP case study

Aggressiveness, inhibitory control, and emotional states: A provocation paradigm

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