Dissociating contributions of ventral and dorsal striatum to reward learning

Chen, Chong; Omiya, Yuki; Yang, Shuzhen

doi:10.1152/jn.00873.2014

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…We therefore tested, whether VS would code A more strongly for the rewarded compared to the control sequence. Indeed, we found responses to A over and above A′ in lateral VS/putamen 39 (cluster-corrected p < 0.05 in the right hemisphere: peak −24, 14, −8, z = 3.30). But even in an ROI centered on this coordinate, none of the other tests described above were significant (one-sample t -tests: all p > 0.1; Fig.…”

Section: Resultsmentioning

confidence: 80%

Multiple associative structures created by reinforcement and incidental statistical learning mechanisms

et al. 2019

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Learning the structure of the world can be driven by reinforcement but also occurs incidentally through experience. Reinforcement learning theory has provided insight into how prediction errors drive updates in beliefs but less attention has been paid to the knowledge resulting from such learning. Here we contrast associative structures formed through reinforcement and experience of task statistics. BOLD neuroimaging in human volunteers demonstrates rigid representations of rewarded sequences in temporal pole and posterior orbito-frontal cortex, which are constructed backwards from reward. By contrast, medial prefrontal cortex and a hippocampal-amygdala border region carry reward-related knowledge but also flexible statistical knowledge of the currently relevant task model. Intriguingly, ventral striatum encodes prediction error responses but not the full RL- or statistically derived task knowledge. In summary, representations of task knowledge are derived via multiple learning processes operating at different time scales that are associated with partially overlapping and partially specialized anatomical regions.

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Section: Resultsmentioning

confidence: 80%

Multiple associative structures created by reinforcement and incidental statistical learning mechanisms

et al. 2019

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“…Regarding the neurobiological basis of the divergent thinking-enhancing effect of walking and stair-climbing, another potential mechanism in addition to the PFC may be the release of dopamine in response to physical activity (Chen et al, 2016(Chen et al, , 2017. This proposal is based on the finding that dopamine is relevant to cognitive flexibility (Klanker et al, 2013) and associative or reinforcement learning (Chen, 2015;Chen et al, 2015), two cognitive processes underlying divergent thinking (Benedek et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Brief Stair-Climbing on Divergent and Convergent Thinking

Matsumoto

Chen

Hagiwara

et al. 2022

Front. Behav. Neurosci.

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Recent studies show that even a brief bout of aerobic exercise may enhance creative thinking. However, few studies have investigated the effect of exercise conducted in natural settings. Here, in a crossover randomized controlled trial, we investigated the effect of a common daily activity, stair-climbing, on creative thinking. As experimental intervention, subjects were asked to walk downstairs from the fourth to the first floor and back at their usual pace. As control intervention, they walked the same path but using the elevator instead. Compared to using the elevator, stair-climbing enhanced subsequent divergent but not convergent thinking in that it increased originality on the Alternate Use Test (d = 0.486). Subjects on average generated 61% more original uses after stair-climbing. This is the first study to investigate the effect of stair-climbing on creative thinking. Our findings suggest that stair-climbing may be a useful strategy for enhancing divergent thinking in everyday life.

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“…As the dorsolateral striatum (DLS) is involved both in the rewarding and motor effects of EtOH and nicotine ( Meng et al, 1998 ; Garção et al, 2013 ; Chen et al, 2014 ), we focused our electrophysiology investigations on this brain region. EtOH and nicotine modulate endocannabinoid signaling in the DLS ( González et al, 2002 ; Marco et al, 2007 ; Adermark et al, 2011 ; Vinod et al, 2012 ; DePoy et al, 2013, 2015 ), and CB1 receptor agonists produce cross-tolerance with both EtOH and nicotine ( Sprague and Craigmill, 1976 ; Siemens and Doyle, 1979 ; da Silva et al, 2001 ; Valjent and Mitchell, 2002 ; Lemos et al, 2007 ; Biała and Budzyńska, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Tolerance to Ethanol or Nicotine Results in Increased Ethanol Self-Administration and Long-Term Depression in the Dorsolateral Striatum

Abburi

Wolfman

Metz

et al. 2016

eneuro

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Ethanol (EtOH) and nicotine are the most widely coabused drugs. Tolerance to EtOH intoxication, including motor impairment, results in greater EtOH consumption and may result in a greater likelihood of addiction. Previous studies suggest that cross-tolerance between EtOH and nicotine may contribute to the abuse potential of these drugs. Here we demonstrate that repeated intermittent administration of either EtOH or nicotine in adult male Sprague Dawley rats results in tolerance to EtOH-induced motor impairment and increased EtOH self-administration. These findings suggest that nicotine and EtOH cross-tolerance results in decreased aversive and enhanced rewarding effects of EtOH. Endocannabinoid signaling in the dorsolateral striatum (DLS) has been implicated in both EtOH tolerance and reward, so we investigated whether nicotine or EtOH pretreatment might modulate endocannabinoid signaling in this region. Using similar EtOH and nicotine pretreatment methods resulted in increased paired-pulse ratios of evoked EPSCs in enkephalin-positive medium spiny neurons in DLS slices. Thus, EtOH and nicotine pretreatment may modulate glutamatergic synapses in the DLS presynaptically. Bath application of the CB1 receptor agonist Win 55,2-212 increased the paired-pulse ratio of evoked EPSCs in control slices, while Win 55,2-212 had no effect on paired-pulse ratio in slices from either EtOH- or nicotine-pretreated rats. Consistent with these effects, nicotine pretreatment occluded LTD induction by high-frequency stimulation of the corticostriatal inputs to the dorsolateral striatum. These results suggest that nicotine and EtOH pretreatment modulates striatal synapses to induce tolerance to the motor-impairing effects of EtOH, which may contribute to nicotine and EtOH coabuse.

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Dissociating contributions of ventral and dorsal striatum to reward learning

Abstract: Chen C, Omiya Y, Yang S. Dissociating contributions of ventral and dorsal striatum to reward learning.

Cited by 14 publications

References 13 publications

Multiple associative structures created by reinforcement and incidental statistical learning mechanisms

Multiple associative structures created by reinforcement and incidental statistical learning mechanisms

The Effect of Brief Stair-Climbing on Divergent and Convergent Thinking

Tolerance to Ethanol or Nicotine Results in Increased Ethanol Self-Administration and Long-Term Depression in the Dorsolateral Striatum

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