Dissociating semantic and phonological maintenance using fMRI

Shivde, Geeta; Thompson-Schill, Sharon L.

doi:10.3758/cabn.4.1.10

Cited by 78 publications

(72 citation statements)

References 45 publications

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“…Consistent with previous studies reporting activation in response to phonological tasks with heard and written words [Burton et al, 2003;Devlin et al, 2003;Fujimaki et al, 1999;Gold et al, 2005;Gold and Buckner, 2002;McDermott et al, 2003;Mummery et al, 1998;Poldrack et al, 1999;Price et al, 1997;Roskies et al, 2001;Shivde and Thompson-Schill, 2004], phonological decisions on pictures of objects (relative to semantic, perceptual, and resting conditions) activated bilateral inferior frontal, insula, precentral, and posterior lateral inferior temporal cortices, supramarginal gyri, ante-rior cingulate, supplementary motor area (SMA), cerebellum, and the left thalamus (Table IV). Critically, these phonological activations included 6 of 12 areas that were more activated in the object-naming meta-analysis for low Ͼ high baselines (all in the left hemisphere): frontal operculum (fo); inferior frontal (if-t); cerebellum (cb), insula (in); thalamus (th); and cingulate gyrus (cg).…”

Section: Phonological Activationsupporting

confidence: 89%

“…To our knowledge, no previous study has reported such a comparison, even though there are numerous functional imaging reports that have compared semantic and phonological tasks when the stimuli are written words [Burton et al, 2003;Devlin et al, 2003;Fujimaki et al, 1999;Gold et al, 2005;Gold and Buckner, 2002;McDermott et al, 2003;Mummery et al, 1998;Poldrack et al, 1999;Price et al, 1997;Roskies et al, 2001;Shivde and Thompson-Schill, 2004]. These previous studies of written word processing have shown consistently that activation is enhanced for phonological relative to semantic decisions in posterior inferior frontal and supramarginal gyri (BA40), and semantic relative to phonological decisions in anterior inferior frontal, the angular gyrus, and posterior and middle temporal areas.…”

Section: Figurementioning

confidence: 98%

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Meta‐analyses of object naming: Effect of baseline

Price¹,

Devlin²,

Moore³

et al. 2005

Human Brain Mapping

181

128

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Abstract:The neural systems sustaining object naming were examined using the activation likelihood estimation (ALE) meta-analysis approach on the results of 16 previously published studies. The activation task in each study required subjects to name pictures of objects or animals, but the baseline tasks varied. Separate meta-analyses were carried out on studies that used: (1) high-level baselines to control for speech processing and visual input; and (2) low-level baselines that did not control for speech or complex visual processing. The results of the two meta-analyses were then compared directly, revealing a double dissociation in the activation pattern for studies using high and low baselines. To interpret the differential activations, we report two new functional imaging experiments. The aim of the first was to characterize activation differences associated with visual stimuli that are typically used in baseline conditions (complex visual features, simple structures, or fixation). The aim of the second was to classify object-naming regions in terms of whether they were engaged preferentially by semantic or phonological processes. The results reveal a remarkably precise correspondence between the areas identified by the meta-analyses as affected differentially by baseline and the areas that are affected differentially by non-object structure, semantics or phonology. As expected, high-level baselines reduced object-naming activation in areas associated with the processing of complex visual features and speech production. In addition, high-level baselines increased sensitivity to activation in areas associated with semantic processing, visual-speech integration and response selection. For example, activation in the anterior temporal areas that neuropsychological studies have associated with semantic processing was more strongly activated in the context of high-level baselines. These results therefore have implications for understanding the convergence of functional imaging and neuropsychological findings. Hum Brain Mapp 25:70 -82, 2005.

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Section: Phonological Activationsupporting

confidence: 89%

Section: Figurementioning

confidence: 98%

Meta‐analyses of object naming: Effect of baseline

Price¹,

Devlin²,

Moore³

et al. 2005

Human Brain Mapping

181

128

View full text Add to dashboard Cite

show abstract

“…There is a distinction in this region between anterior and posterior areas of this region, which seem to be relatively specialized for either semantic (the anterior part (BA 45/47/10)) or phonological (posterior regions (BA 44/6)) processing. The posterior regions of the brain activated in these tasks seem to have a relatively greater involvement in retrieval of stored information such as word meaning (BA21) (Demb et al, 1995;McDermott et al, 2003;Poldrack et al, 1999;Shivde & Thompson-Schill, 2004) or sound (BA7/40) (McDermott et al, 2003;Shivde & Thompson-Schill, 2004). Therefore, the findings on our activation maps correlate with the general knowledge about the distribution of the semantic and phonological networks in the brain (Crosson et al, 2003;Devlin et al, 2003;McDermott et al, 2003;Poldrack et al, 1999;Thompson-Schill et al, 1997).…”

Section: Discussionsupporting

confidence: 70%

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Tivarus¹,

Hillier²,

Schmalbrock³

et al. 2008

Brain and Language

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We describe an fMRI experiment examining the functional connectivity (FC) between regions of the brain associated with semantic and phonological processing. We wished to explore whether L-Dopa administration affects the interaction between language network components in semantic and phonological categorization tasks, as revealed by FC. We hypothesized that L-Dopa would decrease FC due to restriction of the semantic network. During two test sessions (placebo and L-Dopa) each participant performed two fMRI runs, involving phonological and semantic processing. A number of brain regions commonly activated by the two tasks were chosen: left inferior frontal, left posterior temporal and left fusiform gyri, and left parietal cortex. FC was calculated and further analyzed for effects of either the drug or task. No drug effect was found. A significant main effect for task was found, with a greater average correlation for the phonological task than for the semantic task. These findings suggest that language areas are activated in a more synchronous manner for phonological tasks than for semantic tasks. This may relate to the fact that phonological tasks are mediated to a greater extent within language areas, whereas semantic tasks likely require greater interaction outside of the language areas. Alternatively, this may be due to differences in the attentional requirements of the two tasks.

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“…The inferior frontal region, including the insula and inferior frontal gyrus, activates when subjects are asked to remember and make decisions about both words and nonmeaningful phonological stimuli (Chee et al, 2004;Dehaene-Lambertz et al, 2005;Gelfand and Bookheimer, 2003;Jacquemot et al, 2003;LoCasto et al, 2004;Seghier et al, 2004;Shivde and Thompson-Schill, 2004). Similar to activation in the left temporal region, we might also expect less effort devoted to phonological maintenance would be associated with familiar words, resulting in a negative correlation with the task performance.…”

Section: Phonological Processesmentioning

confidence: 99%

Object identification and lexical/semantic access in children: A functional magnetic resonance imaging study of word‐picture matching

Schmithorst

Holland

Plante

2006

Human Brain Mapping

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Theoretical models for lexical access to visual objects have been based mainly on adult data. To investigate the developmental aspects of object recognition and lexical access in children, a largescale functional MRI (fMRI) study was performed in 283 normal children ages 5−18 using a wordpicture matching paradigm in which children would match an aurally presented noun to one of two pictures (line drawings). Using group Independent Component Analysis (ICA), six task-related components were detected, including (a) the posterior superior temporal gyrus bilaterally; (b) the fusiform, inferior temporal, and middle occipital gyri bilaterally; (c) the dorsal aspect of the inferior frontal gyrus bilaterally, the left precuneus, the left superior/middle temporal gyrus, and the anterior cingulate; (d) the right medial fusiform gyrus; (e) a left-lateralized component including the inferior/ middle frontal, middle temporal, medial frontal, and angular gyri, as well as the thalamus and the posterior cingulate; and (f) the ventral/anterior aspect of the inferior frontal gyrus bilaterally. Increased activation associated with age was seen in the components (b) and (d) (ventral visual pathway) for object recognition, and (c) and (f) likely associated with semantic maintenance and response selection. Increased activation associated with task performance was seen in components (b) and (d) (ventral visual pathway) while decreased activation associated with task performance was seen in component (f) (ventral/anterior inferior frontal gyrus). The results corroborate the continued development of the ventral visual pathway throughout the developmental period.

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Dissociating semantic and phonological maintenance using fMRI

Cited by 78 publications

References 45 publications

Meta‐analyses of object naming: Effect of baseline

Meta‐analyses of object naming: Effect of baseline

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Object identification and lexical/semantic access in children: A functional magnetic resonance imaging study of word‐picture matching

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