Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

Peng, Meng; Chen, Shuohua; Jiang, Xiongjing; Zhang, Weiguo; Wang, Yanxiu; Wu, Shouling

doi:10.2169/internalmedicine.55.5898

Cited by 9 publications

(14 citation statements)

References 38 publications

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“…However, all participants in the present study worked in a laboratory during typical sunlight hours (~8 a.m. to 6 p.m.), and thus their sunlight exposure was minimal, which was the probable cause for their vitamin D deficiency, and is in accordance with previous studies (19,20). Roomi et al (18) concluded that indoor occupations were associated with hypovitaminosis D, and a later study on coal mine workers identified vitamin D deficiency and insufficiency among the participants (21). Furthermore, a study in Korea (22) demonstrated that occupational factors including shift work (shifts from 2 pm to midnight, 9 pm to 8 am the following day and 24-hour shifts) and office work were associated with an increased risk of vitamin D deficiency.…”

Section: Discussionsupporting

confidence: 90%

Efficacy of high dose vitamin D supplementation in improving serum 25-hydroxyvitamin D among laboratory personnel working at the Nepal National Center for Rheumatic Diseases

Giri¹,

Upreti²,

Joshi³

et al. 2017

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Abstract. Vitamin D deficiency is a highly prevalent condition worldwide. However, few studies have been conducted to examine the vitamin D status of laboratory personnel and the correlation between vitamin D deficiency and working conditions. The aim of the present study was to assess changes in serum 25-hydroxyvitamin D [25(OH)D] concentration with a weekly dose of oral cholecalciferol (60,000 IU) for two months. The prospective, open-label, interventional study was conducted from January 2016 to March 2016 at the National Centre for Rheumatic Diseases, Kathmandu, Nepal. The serum level of 25(OH)D in 19 healthy laboratory volunteers was measured at baseline and following the 2-month regimen with cholecalciferol supplement at 60,000 IU (1,500 µg)/week in oral tablet form. At baseline the mean serum 25(OH)D level was 10.31±7.78 ng/ml, which was increased following completion of the course of oral cholecalciferol to 59.78±14.74 ng/ml. This difference in the mean serum level of 25(OH)D compared with baseline was significant to P<0.001. These results indicate that vitamin D deficiency is prevalent among laboratory workers, and that high dose vitamin D3 (60,000 IU cholecalciferol) in tablet form may be effective in achieving sufficient serum 25(OH)D among laboratory personnel who tend to have lower baseline serum 25(OH)D. In conclusion, vitamin D deficiency may be common among laboratory workers, and guidelines should be formulated to implement vitamin D supplementation among laboratory personnel, as well as indoor workers, in Nepal.

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Section: Discussionsupporting

confidence: 90%

Efficacy of high dose vitamin D supplementation in improving serum 25-hydroxyvitamin D among laboratory personnel working at the Nepal National Center for Rheumatic Diseases

Giri¹,

Upreti²,

Joshi³

et al. 2017

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“…Logistic regression analysis failed to determine a significant association between vitamin-D status and hypertension. More studies are required to establish an association between vitamin-D levels and hypertension (Peng et al, 2016).…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

Health implications of exposure to coal mine dust in workers –A Review

Ganesan¹,

Sangeetha²

2019

ijrps

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Major health problem for workers is prevalent in all nations due to occupational hazards. Coal mining is one of the largest and oldest industries in the world. However, no such information is available in the literature regarding the health status of coal mine workers. Coal is a basic necessity for the production of electricity and steel. Along with machines, humans are the workforce in every coal mine industry. Air pollutants and dust mixed with silica are the two major factors that affect the health of coal mine workers. Coal mine workers run the risk of getting respiratory damage due to high levels of dust and other chemical particulate matters. Some of the disorders caused by coal mines are Chronic Pulmonary Obstructive Disease (COPD), Coal Workers Pneumoconiosis (CWP), Asthma and massive fibrosis. Prolonged exposure to coal mine dust may cause a variety of diseases like Tuberculosis, Chronic Bronchitis, Heart Diseases, Lung Cancer, Pneumonia, liver disease, kidney damage, DM and Reproductive disorders. All these diseases may be induced if mine workers are subjected to prolonged exposure. This review article highlights the outcome of research works done in the past three decades on the health implications of coal mine workers. Further studies are required with respect to the degree of damage to each organ and to prepare a set of guidelines to be followed by coal mine industries to be strictly followed to safeguard the wellbeing of coal mine workers.

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“…It is well known that primary hyperparathyroidism is associated with established HT and that parathyroidectomy significantly reduces blood pressure (BP) [ 6 , 7 ]. In addition, the association between BP and serum vitamin D and PTH levels has been widely studied [ 8 – 11 ]. While some authors reported an association between BP, serum vitamin D and PTH levels [ 8 , 9 ], others did not find any relation [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the association between BP and serum vitamin D and PTH levels has been widely studied [ 8 – 11 ]. While some authors reported an association between BP, serum vitamin D and PTH levels [ 8 , 9 ], others did not find any relation [ 10 , 11 ]. Almost all of these investigations were conducted on HT patients who were receiving antihypertensive treatment [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…While some authors reported an association between BP, serum vitamin D and PTH levels [ 8 , 9 ], others did not find any relation [ 10 , 11 ]. Almost all of these investigations were conducted on HT patients who were receiving antihypertensive treatment [ 8 – 11 ]. One study showed that use of furosemide and dihydropyridine calcium-channel blockers was associated with higher PTH levels [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of parathyroid hormone and vitamin D with untreated hypertension: Is it different in white-coat or sustained hypertension?

et al. 2017

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BackgroundPrevious reports about the relationship between a high parathyroid hormone (PTH) and low vitamin D levels with blood pressure in different hypertension groups are conflicting.ObjectiveWe studied serum PTH and vitamin D levels in white-coat (WCHT) and sustained hypertension (SHT) patients who had not been on antihypertensive treatment. We also investigated the association between serum PTH and vitamin D levels with respect to blood pressure in SHT and WCHT patients.MethodsWe included 52 SHT patients (54.06 ± 9.2 years, 32 newly diagnosed and 20 previously diagnosed with SHT who had not been treated with antihypertensive medication for 3 months or more), 48 WCHT patients (53.64 ± 9.5 years), and 50 normotensive (NT) healthy controls (53.44 ± 8.4 years) in our study. In addition to routine tests, PTH and vitamin D levels were measured.ResultsSerum PTH levels were significantly higher in SHT patients not taking antihypertensive medications than in WCHT patients and NT controls (p = 0.004). Although PTH levels were higher in WCHT than in NT groups, the difference was not statistically significant. In SHT patients, PTH levels showed a positive correlation with office systolic (r = 0.363, p = 0.008), office diastolic (r = 0.282, p = 0.038), home systolic (r = 0.390, p = 0.004), and home diastolic blood pressures (r = 0.397, p = 0.003). Serum vitamin D levels were similar in SHT, WCHT and NT groups. Vitamin D levels were not associated with blood pressures in the entire study group. Furthermore, no significant relation was found between vitamin D and PTH levels in SHT and WCHT groups.ConclusionPTH levels are significantly higher in untreated SHT patients than WCHT patients and NT subjects. However, vitamin D levels are similar in SHT, WCHT and NT groups. There is a significant association between PTH levels and blood pressures suggesting PTH has a role in increase of blood pressure in SHT.

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Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

Cited by 9 publications

References 38 publications

Efficacy of high dose vitamin D supplementation in improving serum 25-hydroxyvitamin D among laboratory personnel working at the Nepal National Center for Rheumatic Diseases

Efficacy of high dose vitamin D supplementation in improving serum 25-hydroxyvitamin D among laboratory personnel working at the Nepal National Center for Rheumatic Diseases

Health implications of exposure to coal mine dust in workers –A Review

Association of parathyroid hormone and vitamin D with untreated hypertension: Is it different in white-coat or sustained hypertension?

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