Dissociation Constants of Some Compounds Related to Lysergic Acid

Abstract

Dissociation constants have been recorded for ergometrine, ergometrinine and a number of alkanolamides of 3‐dimefhylaminopropionic acid, 1‐methylhexahydronicotinic acid and arecaidine. The similarity of ΔpK (amide) values for the alkanolamides with that for ergometrine, offers evidence that such values may be taken as an indicator of amino‐carboxyl distances.

Spectroscopic Determination of Acid Dissociation Constants of Some Pyridyl-Substituted 2-Aminothiazole Derivatives

“…The acid dissociation constants have been used in various areas of research such as stereochemical and conformational structure determinations, , the directions of nucleophilic and electrophilic attack, the stabilities of intermediates, the size of activation energies in organic reactions, and the determination of the active centers of enzymes in biochemistry . In the present work, we are reporting on the experimental acid dissociation constants of some biologically active 4-( x -pyridyl)-2- aminothiazole bases to elucidate the structure−reactivity relations.…”

Spectroscopic Determination of Acid Dissociation Constants of Some Biologically Active 6-Phenyl-4,5-dihydro-3(2H)-pyridazinone Derivatives

“…Therefore, knowledge about the structure of heteroaromatic molecules is invaluable in understanding their reactivity. The acid dissociation constants have been used in various areas of research, such as stereochemical and conformational structure determinations, 1,2 the directions of nucleophilic and electrophilic attack, the stabilities of intermediates, the size of activation energies in organic reactions, 3 and determination of the active centers of enzymes in biochemistry. 4 In the present work we report on the acid-base behavior of some 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives with potential antihypertensive effects.…”

Determination and Evaluation of Acid Dissociation Constants of Some Substituted 2-Aminobenzothiazole Derivatives

“…Acid dissociation constants can be used in various areas of research, such as stereochemical and conformational structure determinations, 23,24 the directions of nucleophilic and electrophilic attack, the stabilities of intermediates, the size of activation energies in organic reactions, 25 and determination of the active centers of enzymes in biochemistry. 26 In the present work, we report on the experimental acid dissociation constants of some biologically active 4-and/or 6-substituted 2-amino benzothiazole bases to elucidate the structure-reactivity relationships and to evaluate the linear free energy relationship.…”