Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

Thomson, David M.; McVie, Allan; Morris, Brian J.; Pratt, Judith A.

doi:10.1007/s00213-010-2020-7

Cited by 29 publications

(22 citation statements)

References 71 publications

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“…For example, chronic intermittent PCP in adult male rats (2.58 mg/kg; i.p. ; daily for 5 days and then 3 days per week for 3 weeks) produces a reduction in the speed of processing 24h but not 30 min post-treatment (Thomson et al, 2011). Similar results were observed in repeated PCP-treated rats (2 mg/kg; s.c.; 2 consecutive days, followed by a 2-week PCP-free period and then 5 consecutive days of PCP treatment, given 30-min before 5-CSRTT testing) (Amitai and Markou, 2009;Amitai et al, 2007).…”

Section: Speed Of Processingsupporting

confidence: 86%

A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies

Léger

Neill

2016

Neuroscience & Biobehavioral Reviews

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Section: Speed Of Processingsupporting

confidence: 86%

A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies

Léger

Neill

2016

Neuroscience & Biobehavioral Reviews

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“…Indeed, several studies reported that NMDA antagonists (other than ketamine) increase impulsivity in the 5-CSRTT. That is the case of acute treatment with MK-801 or phencyclidine (Paine and Carlezon, 2009; Thomson et al, 2011; Barnes et al, 2012). Similarly, our group has shown that an acute challenge with MK-801 is able to increase all measures of impulsive behavior in the VDS (Leite-Almeida et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, our group has shown that an acute challenge with MK-801 is able to increase all measures of impulsive behavior in the VDS (Leite-Almeida et al, 2013). On the other hand, chronic treatment may display a different behavioral pattern, either reduced PR during a 24-h drug withdrawal (Paine and Carlezon, 2009) or had no effect (Thomson et al, 2011; Barnes et al, 2012). Until now, most research seems to show a tendency of NMDA antagonists to increase impulsive behavior after an acute exposure, while on sub-chronic and chronic regimens the response seems to be towards a decrease in impulsive response particularly if the test is made during the withdrawn period.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Ketamine Anesthesia Affects Rat Impulsive Behavior

Melo

Leite‐Almeida

Ferreira

et al. 2016

Front. Behav. Neurosci.

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Introduction: Ketamine is a general anesthetic (GA) that activates several neurotransmitter pathways in various part of the brain. The acute effects as GA are the most well-known and sought-after: to induce loss of responsiveness and to produce immobility during invasive procedures. However, there is a concern that repeated exposure might induce behavioral changes that could outlast their acute effect. Most research in this field describes how GA affects cognition and memory. Our work is to access if general anesthesia with ketamine can disrupt the motivational behavior trait, more specifically measuring impulsive behavior.Methods: Aiming to evaluate the effects of exposure to repeat anesthetic procedures with ketamine in motivational behavior, we tested animals in a paradigm of impulsive behavior, the variable delay-to-signal (VDS). In addition, accumbal and striatal medium spiny neurons morphology was assessed.Results: Our results demonstrated that previous exposure to ketamine deep-anesthesia affects inhibitory control (impulsive behavior). Specifically, ketamine exposed animals maintain a subnormal impulsive rate in the initial periods of the delays. However, in longer delays while control animals progressively refrain their premature unrewarded actions, ketamine-exposed animals show a different profile of response with higher premature unrewarded actions in the last seconds. Animals exposed to multiple ketamine anesthesia also failed to show an increase in premature unrewarded actions between the initial and final periods of 3 s delays. These behavioral alterations are paralleled by an increase in dendritic length of medium spiny neurons of the nucleus accumbens (NAc).Conclusions: This demonstrates that ketamine anesthesia acutely affects impulsive behavior. Interestingly, it also opens up the prospect of using ketamine as an agent with the ability to modulate impulsivity trait.

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“…The protocol was according to our standard procedures (Thomson et al 2011). Mice were first habituated to the liquid reinforcer (Yazoo® Strawberry Milkshake) and operant boxes before undergoing 10 stages of training, which took 65 daily sessions in total.…”

Section: Methodsmentioning

confidence: 99%

Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

et al. 2016

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RationaleMembers of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear.ObjectiveIn the current study, we test the hypothesis that reduced MKK7 expression is sufficient to cause cognitive impairment.MethodsAttentional function in mice haploinsufficient for Map2k7 (Map2k7 +/− mice) was investigated using the five-choice serial reaction time task (5-CSRTT).ResultsOnce stable performance had been achieved, Map2k7 +/− mice showed a distinctive attentional deficit, in the form of an increased number of missed responses, accompanied by a more pronounced decrement in performance over time and elevated intra-individual reaction time variability. When performance was reassessed after administration of minocycline—a tetracycline antibiotic currently showing promise for the improvement of attentional deficits in patients with schizophrenia—signs of improvement in attentional performance were detected.ConclusionsOverall, Map2k7 haploinsufficiency causes a distinctive pattern of cognitive impairment strongly suggestive of an inability to sustain attention, in accordance with those seen in psychiatric patients carrying out similar tasks. This may be important for understanding the mechanisms of cognitive dysfunction in clinical populations and highlights the possibility of treating some of these deficits with minocycline.Electronic supplementary materialThe online version of this article (doi:10.1007/s00213-016-4463-y) contains supplementary material, which is available to authorized users.

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Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

Cited by 29 publications

References 71 publications

A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies

A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies

Exposure to Ketamine Anesthesia Affects Rat Impulsive Behavior

Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

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