Dissociation of Analgesic and Hormonal Responses to Forced Swim Stress Using Opioid Receptor Knockout Mice

Contet, Candice; Gavériaux‐Ruff, Claire; Matifas, Audrey; Caradec, Claudia; Champy, Marie‐France; Kieffer, Brigitte L.

doi:10.1038/sj.npp.1300934

Cited by 71 publications

(40 citation statements)

References 84 publications

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“…These studies suggest that compared to met-HQNHSKDOLQ ȕ-endorphin plays a more prominent role in the expression of SIA. In addition, female transgenLF PLFH ODFNLQJ ȝ-RU į-opioid receptors did not express SIA assessed in the hot plate test following forced swim stress (Contet et al, 2006).…”

Section: Mediation and Modulation Of Sia By The Opioid Systemmentioning

confidence: 81%

Stress-Induced Analgesia

Tricklebank¹,

Curzon²

2013

Encyclopedia of Pain

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Abbreviations: SIA, stress-induced analgesia; FCA, fear-conditioned analgesia; GABA, Ȗ-aminobutyric acid; HA, high analgesia; LA, low analgesia; fMRI, functional magnetic resonance imaging; DNIC, diffuse noxious inhibitory control; PAG, periaqueductal grey; RVM, rostroventral medulla; 5-HT, 5-hydroxytryptamine; CB 1 , cannabinoid type 1; CB 2 , cannabinoid type 2; NMDA, N-methyl-D-aspartic acid; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; mGluR, metabotropic glutamate receptor; NK1, neurokinin 1; SP, substance P; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; MGL, monoacylglycerol lipase; HPA, hypothalamo-pituitary-adrenal; ACTH, adrenocorticotropic hormone 3 ABSTRACT For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stressinduced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia sensitivity can vary a great deal depending on age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway.Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the HQGRJHQRXV RSLRLG PRQRDPLQH FDQQDELQRLG Ȗ-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and has been a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.4

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Section: Mediation and Modulation Of Sia By The Opioid Systemmentioning

confidence: 81%

Stress-Induced Analgesia

Tricklebank¹,

Curzon²

2013

Encyclopedia of Pain

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“…Interestingly, naltrindole (delta antagonist)-induced immunosuppression was maintained in spleen cells from T-OpR KO mice, suggesting the involvement of another unknown molecular target (Gaveriaux-Ruff et al 2001). Also, a slightly enhanced sensitivity to acute pain was observed in T-OpR KO animals indicating a low endogenous opioid tone for nociception (see Contet et al 2006). In addition, stressinduced analgesia under mild conditions was abolished in T-OpR KO mice, implying opioid brain circuits for this stress response (Contet et al 2006).…”

Section: Introductionmentioning

confidence: 94%

“…Also, a slightly enhanced sensitivity to acute pain was observed in T-OpR KO animals indicating a low endogenous opioid tone for nociception (see Contet et al 2006). In addition, stressinduced analgesia under mild conditions was abolished in T-OpR KO mice, implying opioid brain circuits for this stress response (Contet et al 2006).…”

Section: Introductionmentioning

confidence: 94%

Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors

Karaji

Reiss

Matifas

et al. 2011

J Neuroimmune Pharmacol

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Here, we evaluated the influence of endogenous opioid activation on immune responses by examining consequences of all three opioid receptor gene (mu, delta and kappa) inactivation. In triple-opioid receptor knockout mice, splenocytes and thymocytes numbers, lymphocyte subsets as well as proliferation and cytokines induced by in vitro stimulation of T lymphocytes were measured. Compared with wild-type mice, similar lymphocyte distribution in thymus and spleen as well as comparable T lymphocyte proliferation were observed, while lower levels of IL-2 and IFNγ as well as higher levels of IL-4 and IL-10 were found in triple-opioid receptor knockout mice. Together, our results indicate a shift from TH1 to TH2 cytokines in triple-opioid receptor knockout animals, suggesting that global endogenous opioid tone drives T lymphocytes toward a TH1 profile under non-pathological conditions.

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“…Liberación por el ejercicio intenso de beta endorfinas del sistema opioide con un efecto anticonvulsivante (66,67).…”

Section: ¿Cómo Se Explica Que El Ejercicio Disminuya El Número De Criunclassified

Epilepsia y actividad física: conceptos desde la perspectiva de las ciencias básicas

Carrizosa-Moog

2017

iatreia

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Recibido: marzo 18 de 2016 Aceptado: octubre 12 de 2016Cómo citar: Carrizosa-Moog J. Epilepsia y actividad física: conceptos desde la perspectiva de las ciencias básicas. Iatreia. 2017 Jul-Sept;30(3): 287-296. DOI 10.17533/udea.iatreia.v30n3a04. RESUMENLa Organización Mundial de la Salud considera que la epilepsia es una prioridad de salud pública. A las personas afectadas se les restringe con frecuencia su participación en actividades físicas y deportivas, pero los estudios clínicos han demostrado un efecto benéfico de la actividad física sobre el control de las crisis epilépticas. Se describen los hallazgos desde la perspectiva de las ciencias básicas que demuestran los mecanismos reguladores del efecto del ejercicio sobre la epileptogénesis, el control de la enfermedad y de su comorbilidad psiquiátrica. Tanto las investigaciones clínicas como las básicas indican que se debería considerar la actividad física como una estrategia terapéutica complementaria en las personas con epilepsia, la cual está disponible en todas partes del mundo y a un muy bajo costo. PALABRAS CLAVEDeporte; Epilepsia; Ejercicio; Investigación Básica SUMMARY Epilepsy and physical activity: concepts from the perspective of basic sciences According to the World Health Organization, epilepsy is a public health priority. Persons with this disease are frequently restricted from participating in physical activities and sports. Clinical studies have shown the beneficial effects of exercise on seizure control. Results from basic research demonstrating the mechanisms of physical activity on epileptogenesis, seizure

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Dissociation of Analgesic and Hormonal Responses to Forced Swim Stress Using Opioid Receptor Knockout Mice

Cited by 71 publications

References 84 publications

Stress-Induced Analgesia

Stress-Induced Analgesia

Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors

Epilepsia y actividad física: conceptos desde la perspectiva de las ciencias básicas

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