In this paper, quarkonium dissociation is investigated in an anisotropic plasma in the hot and dense media. For that purpose, the multidimensional Schrödinger equation is solved analytically by Nikiforov-Uvarov (NU) method for the real part of the potential in an anisotropic medium. The binding energy and dissociation temperature are calculated. In comparison with an isotropic medium, the binding energy of quarkonium is enhanced in the presence of an anisotropic medium. The present results show that the dissociation temperature increases with increasing anisotropic parameter for 1S state of the charmonium and bottomonium. We observe that the lower baryonic chemical potential has small effect in both isotropic and anisotropic media. A comparison is presented with other pervious theoretical works.