2021
DOI: 10.3389/fpsyt.2021.699292
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Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder

Abstract: Default mode network (DMN) plays a key role in the pathophysiology of in bipolar disorder (BD). However, the homogeneity of this network in BD is still poorly understood. This study aimed to investigate abnormalities in the NH of the DMN at rest and the correlation between the NH of DMN and clinical variables in patients with BD. Forty drug-naive patients with BD and thirty-seven healthy control subjects participated in the study. Network homogeneity (NH) and independent component analysis (ICA) methods were u… Show more

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Cited by 1 publication
(2 citation statements)
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“…Subsequently, they could induce overactivation of the hypothalamus–pituitary–adrenal axis, resulting in heightened hormone levels in the central nervous system and the attenuation of negative feedback regulation. This, in turn, may lead to metabolic issues such as elevated blood sugar (Li, Teng et al., 2021 ). It is plausible that, among patients with MDD, the impact of depressive symptoms may contribute to a diminished appetite and reduced food intake, culminating in decreased lipid levels.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Subsequently, they could induce overactivation of the hypothalamus–pituitary–adrenal axis, resulting in heightened hormone levels in the central nervous system and the attenuation of negative feedback regulation. This, in turn, may lead to metabolic issues such as elevated blood sugar (Li, Teng et al., 2021 ). It is plausible that, among patients with MDD, the impact of depressive symptoms may contribute to a diminished appetite and reduced food intake, culminating in decreased lipid levels.…”
Section: Discussionmentioning
confidence: 99%
“…Network homogeneity (NH), a method proposed by Uddin et al primarily investigates functional connectivity between specific voxels within a particular network such as the DMN (Li, Teng et al, 2021).…”
Section: Introductionmentioning
confidence: 99%