Readers' eye movements were monitored as they read sentences containing lexically ambiguous words whose meanings share a single syntactic category (e.g., calf), lexically ambiguous words whose meanings belong to different syntactic categories (e.g., duck), or unambiguous control words. Information provided prior to the target always unambiguously specified the context-appropriate syntactic-category assignment for the target. Fixation times were longer on ambiguous words whose meanings share a single syntactic category than on controls, both when prior context was semantically consistent with the subordinate interpretation of a biased ambiguous word (Experiment 1) and when prior context was semantically neutral as to the intended interpretation of a balanced ambiguous word (Experiment 2). These ambiguity effects, which resulted from differences in difficulty with meaning resolution, were not found when the ambiguity crossed syntactic categories. These data indicate that, in the absence of syntactic ambiguity, syntactic-category information mediates the semantic-resolution process.