Dissociative states in borderline personality disorder and their relationships to psychotropic medication

Pěč, Ondřej; Bob, Petr; Simek, J; Raboch, Jiří

doi:10.2147/ndt.s179091

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…These domains are primary domains for defining borderline PD based on both, the ICD-11 personality trait qualifiers (11,16,20) and IPDEQ self-assessment. To some extent, the tertiary correlation of both types of emotionally unstable PD (i.e., borderline and impulsive) on the Psychoticism domain confirms the clinical experience with the quasi-psychotic phenomena and transient dissociative states in this group of patients (55,56).…”

Section: Predictive Validitysupporting

confidence: 76%

Psychometric Properties of the Independent 36-Item PID5BF+M for ICD-11 in the Czech-Speaking Community Sample

2021

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Background: Empirical soundness and international robustness of the PID5BF+M, a shortened version of the PID-5 developed for simultaneous evaluation of maladaptive personality traits in the DSM-5 AMPD and ICD-11 models for personality disorders, was recently confirmed in 16 samples from different countries. Because the modified PID5BF+ scale (36 items) was extracted from the complete 220-item PID-5, an independent evaluation of psychometric properties of a stand-alone PID5BF+M is still missing.Objectives: The present study evaluated the validity and reliability of the 36-item PID5BF+M in comparison with the extracted version from the original PID-5. It also assessed associations between the Borderline Pattern qualifier and trait domain qualifiers.Methods: Two non-clinical samples meeting the inclusion criteria were employed in the study. Sample 1 (n = 614) completed the 220-item PID-5; Sample 2 (n = 1,040) completed the independent 36-item PID5BF+M. Participants were from all 14 regions of the Czech Republic. The Borderline Pattern qualifier was evaluated using a shortened IPDEQ screener.Results: The proposed latent structure of the independent PID5BF+M was confirmed, with an exception of the Disinhibition domain. The results confirmed good internal consistency and test-retest reliability of the measure, as well as some support for the measurement invariance of the independent PID5BF+M in comparison with the extracted version from the original PID-5. Significant associations between the Negative affectivity, Disinhibition, and Psychoticism qualifiers and the IPDEQ items for the emotionally unstable personality disorder of both impulsive and borderline types confirmed good predictive validity of the PID5BF+M in pursuing borderline psychopathology within the ICD-11 model.Conclusions: The independent PID5BF+M was found to be a valid and reliable tool for evaluation of the ICD-11 trait model. However, the Disinhibition domain deserves further investigation in clinical samples as well as in international community samples.

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Section: Predictive Validitysupporting

confidence: 76%

Psychometric Properties of the Independent 36-Item PID5BF+M for ICD-11 in the Czech-Speaking Community Sample

2021

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“…It was hypothesized that antipsychotic treatment might decrease activation of the anterior cingulate cortex linked to the detection of cognitive conflict, while a resulting decrease of conscious awareness of conflicting stressful experiences may produce dissociative symptoms measured by DES. [ 56 ] Data of this study show that this hypothesis may also apply to patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 68%

Basic symptoms of schizophrenia are related to symptoms of traumatic stress: A pivotal role of sensitization. An observational study

2022

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Introduction: Subjective cognitive deficits have been broadly reported in schizophrenia and described by Huber as basic symptoms. It remains unclear however to what extent they may be related to psychosocial stressors including trauma.Methods: We assessed basic symptoms using the Frankfurt Complaint Questionnaire (FCQ) in a sample of 40 patients with schizophrenia. Trauma-related symptoms were assessed concurrently using the Trauma Symptom Checklist-40, symptoms of dissociation using the Dissociative Experiences Scale, and sensitization phenomena using the Complex Partial Seizure-like Symptoms Inventory and Limbic System Checklist-33. Psychotic symptoms were measured by Health of the Nation Outcome Scales. The dosage of antipsychotic medication was assessed in terms of equivalents of chlorpromazine, and antidepressant medication in terms of equivalents of fluoxetine. Spearman correlations were performed to explore the relationship between FCQ and other trauma-related measures. To determine the relative contributions of trauma-related symptoms to basic symptoms a linear regression analysis was performed.Results: The results showed that higher levels of basic symptoms of schizophrenia were associated with greater levels of symptoms of dissociation, traumatic stress, and sensitization or kindling-like processes in schizophrenia. Among the traumarelated variables, sensitization phenomena assessed with Complex Partial Seizure-like Symptoms Inventory were closely associated with basic symptoms.Discussion: These results indicate that basic symptoms measured by FCQ might be related to trauma. The potential of trauma to influence neurodevelopmental hypotheses of schizophrenia is discussed.

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“…While Italian psychiatrists reject this approach as expressed in a questionnaire (Aguglia et al 2021), observations in Spain suggest that LAI formulations of risperidone and aripiprazole may have a positive effect (Garcia-Carmona et al 2021), but most of the patients were comedicated with antidepressants, benzodiazepines, and with oral antipsychotics. There is, however, an intriguing report which described a significant positive correlation between dissociative symptoms in borderline PD but not in schizophrenic patients, and drug doses of antipsychotics and antidepressants administered to the patients (Pec et al 2018).…”

Section: Antipsychoticsmentioning

confidence: 97%

Pharmacotherapy of Personality Disorders

Baumann¹,

Herpertz²

2021

NeuroPsychopharmacotherapy

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Personality disorders (PD) represent a group of more than 10 disorders, depending on the diagnostic classification used, but most research on pharmacological treatments deals with borderline PD. International guidelines consider the evidence for the usefulness of psychopharmacotherapy for PD limited and therefore, their major recommendation is to center this therapeutic approach for the treatment of the frequent psychiatric comorbidities. Indeed, current evidence favors psychotherapy compared to psychopharmacotherapy in the treatment of personality disorders (PD). However, antipsychotic drugs, antidepressants, anticonvulsants, and other psychotropic drugs are widely used, very frequently as combination treatments, despite not any of them has been introduced by national P. Baumann

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Dissociative states in borderline personality disorder and their relationships to psychotropic medication

Cited by 11 publications

References 38 publications

Psychometric Properties of the Independent 36-Item PID5BF+M for ICD-11 in the Czech-Speaking Community Sample

Psychometric Properties of the Independent 36-Item PID5BF+M for ICD-11 in the Czech-Speaking Community Sample

Basic symptoms of schizophrenia are related to symptoms of traumatic stress: A pivotal role of sensitization. An observational study

Pharmacotherapy of Personality Disorders

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