Dissolution Enhancement of Drugs. Part II: Effect of Carriers

Abstract

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Tadalafil Inclusion in Microporous Silica as Effective Dissolution Enhancer: Optimization of Loading Procedure and Molecular State Characterization

“…6 Various techniques have been used in attempt to improve solubility and dissolution rates of poorly soluble drugs, which includes solid dispersion, micronization, lipidbased formulations, liquisolid compacts, and complexation. 7,8 The faster release of free drug is thought to be beneficial because, once being administered orally, the quickly released drug may be passively partitioned into the gastrointestinal tract tissues quickly as a result of the favorable concentration gradient resulting into a rapid onset of action and an improved bioavailability.…”

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“…The enhancement of dissolution is mainly attributed to increased surface area of drug exposed to large carrier molecules, increased wettability, and accordingly solubility due to polar effect of sugars containing polar groups. [1] This also may be attributed to the higher hydrophilic sugar carriers, which can reduce the interfacial tension between the poorly aqueous soluble drug and the dissolution medium.…”

“…Attempts to improve the solubility of these drug candidates have been performed by various approaches. [1] Among them, solid dispersion (SD) technique has attracted considerable interest as an efficient means of improving the dissolution rate, which increases the solubility of a range of poorly aqueous soluble drugs. [2][3][4] Fast and immediate drug dissolution from SDs has been observed due to increased wettability, improved dispersibility of drug particles, and existence of the drug in amorphous form with improved solubility and absence of aggregation of drug particles using various hydrophilic carriers.…”

“…[2][3][4] Fast and immediate drug dissolution from SDs has been observed due to increased wettability, improved dispersibility of drug particles, and existence of the drug in amorphous form with improved solubility and absence of aggregation of drug particles using various hydrophilic carriers. [1][2][3][4] Domperidone (DOM) is described chemically as 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazole-1-yl) propyl]-4-piperidinyl1]-1, 3-dihydro-2H-benzimidazole-2-one [ Figure 1]. …”

In vitro dissolution study of atorvastatin binary solid dispersion

“…[2] Among them, solid dispersion (SD) technique has attracted considerable interest as an efficient means of improving the dissolution rate, which increases the bioavailability of a range of poorly aqueous soluble drugs. [34] For last few decades, SD techniques become the common choice of selection for increasing the solubility of poorly soluble drugs because of its ease of preparation, ease of optimization and reproducibility.…”