Dissolution enhancement of glimepiride using modified gum karaya as a carrier

Abstract

Objective:The aim of present investigation is to enhance in vitro dissolution of poorly soluble drug glimepiride by preparing solid dispersions using modified gum karaya.Materials and Methods:Solid dispersions of drug were prepared by solvent evaporation method using modified gum karaya as carrier. Four batches of solid dispersion (SD1, SD4, SD9, and SD14) and physical mixture (PM1, PM4, PM9, and PM14) were prepared and characterized by differential scanning colorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, powder X-Ray diffraction (X-RD), and scanning electron microscopy (SEM) studies. Equilibrium solubility studies were carried out in shaker incubator for 24 h and in vitro drug release was determined using USP Dissolution Apparatus-II.Results:Maximum solubility and in vitro dissolution were observed with Batch SD4. No significant enhancement of dissolution characteristics were observed in the corresponding physical mixture PM4. Low viscosity with comparable swelling characteristics as compared to GK of modified form of gum karaya may lead to improvement in dissolution behavior of solid dispersion batches. Also, the conversion of crystalline form of drug to amorphous form may be a responsible factor, which was further confirmed by DSC, FTIR studies, and X-RD studies. SEM photographs of batch SD4 revealed porous nature of particle surface.Conclusion:Modified forms of natural carriers prove beneficial in dissolution enhancement of poorly soluble drugs and exhibited a great potential in novel drug delivery systems.

Enhancement of <i>In Vitro</i> Skin Transport and <i>In Vivo</i> Hypoglycemic Efficacy of Glimepiride Transdermal Patches

“…FTIR of pure GMD showed characteristic sharp peaks at 3369 cm -1 and 3288 cm -1 due to N-H stretching, 1707 cm -1 and 1674 cm -1 due to carbonyl group, 1345 cm -1 indicating C-N stretching vibration, 1153 cm -1 confirmed S=O stretching vibration [9] as depicted in figure (1A).…”

“…However, GMD as well as with other oral hypoglycemic drugs has shown several adverse and potential side effects related to hypoglycemia with inaccurate dosing. Recently, there is a growing interest to enhance and control the transdermal delivery of GMD using matrix of natural and synthetic materials [6][7][8][9]. The aim of the current study was to develop GMD transdermal patches to control insulin nondependent diabetes (type II).…”

Development of Stable Nanosuspension Loaded Oral Films of Glimepiride With Improved Bioavailability

“…In the earlier studies conducted on glimepiride 40 to 75% improvement in dissolution rate was observed in case of solid dispersions prepared using PVP k-30 as compared to pure drug whereas solid dispersions prepared using guar gum could release only 30% drug within 10 min. [21,22]. Therefore it can be said that formulating nanosuspensions of glimepiride by simple high shear homogenization method using hydrophilic polymer HPMC E-15 which acts as a steric stabilizer could enhance dissolution rate significantly [23] The increase in dissolution profile of GNS2 may be due to an increase in the stirring times during preparation as compared to their respective nanosuspension formulations, which resulted in smaller particle sizes.…”

Enhancement of Dissolution of Furosemide by Solid Dispersion Using Hydrophilic Polymer and Modified Natural Carriers

“…[9] Evaluation Characterization of xanthan gum and modified xanthan gum for viscosity and swelling index. [2,10] Viscosity A 0.5% aqueous solution of sample was added to the viscometer, pulled into the upper reservoir by suction and then allowed to drain by gravity back into the lower reservoir. The time that it takes for the liquid to pass between two etched marks, one above and one bellow the upper reservoir, is measured.…”

“…10 grams of powdered GK was taken in a porcelain bowl and subjected to heating using a sand bath for 2hr at 120 o C. [2,3] Preparation of modified xanthan gum…”