Dissolution Kinetics of Calcium Phosphate Coatings

Burke, Eileen M.; Lucas, L. C.

doi:10.1097/00008505-199807040-00011

Cited by 8 publications

(7 citation statements)

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“…Calcium phosphate (CaP) coated titanium alloys are widely used as orthopedic implant materials4–7 and were found to enhance initial bony ingrowth, therefore stimulating osseous apposition to the implant surface, promoting a rapid fixation of the devices to the skeleton 8–10. The plasma‐sprayed CaP coatings may have different crystallinities 5, 8, 9, 11, 12. The crystallinity is directly related to the dissolution rate of the coating with higher crystallinity being associated with a lower dissolution rate of the coating 5, 8, 9, 11, 12.…”

Section: Introductionmentioning

confidence: 99%

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Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants

Karlis

Anderson

Dunstan

et al. 2008

J Biomedical Materials Res

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Calcium phosphate ceramics are widely used as coating materials to orthopedic implants and are found to enhance initial bony ingrowth by stimulating osseous apposition to the implant surface. In this study, two novel calcium orthophosphate materials were selected for coating onto the commonly used orthopedic implant material Ti-6Al- 4V. One was calcium alkali orthophosphate with the crystalline phase Ca10[K/Na](PO4)7 with a small addition of SiO2 (AW-Si) and the other was calcium orthophosphate composed of 70 mol % fluorapatite, Ca10(PO4)6F2 and 30 mol % CaZr4(PO4)6 (FA7Z). The coated implants were placed in cortical and cortico-cancellous bone of sheep femur for six weeks. Retrieved samples were tested for osseointegration and mechanical strength. It was found that both coatings produced enhanced bone/implant contact rate compared to the control when implanted in cortico-cancellous bone. This study demonstrates that the two coatings have the capability of encouraging bone growth, and hence the potential for being used as coating materials on Ti implants.

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Section: Introductionmentioning

confidence: 99%

“…The plasma‐sprayed CaP coatings may have different crystallinities 5, 8, 9, 11, 12. The crystallinity is directly related to the dissolution rate of the coating with higher crystallinity being associated with a lower dissolution rate of the coating 5, 8, 9, 11, 12. Thus, heat treatments are often applied to increase the crystallinity 9.…”

Section: Introductionmentioning

confidence: 99%

Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants

Karlis

Anderson

Dunstan

et al. 2008

J Biomedical Materials Res

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“…It is known that ACP transforms into apatite under a normal physiological environment, because body fluid (SBF as well) is supersaturated with respect to ACP, apatite, and several other calcium phosphate phases, among which apatite is the most stable and insoluble phase [ 27 ]. However, a decrease in environmental pH from the physiological pH (~7.4) significantly increases the solubility of these calcium phosphates [ 28 ], which may lead to the dissolution and resorption of the relatively unstable ACP phase. The effects of body fluid circulation might also be involved in the dissolution and resorption of the ACP nanoparticles by facilitating the diffusion of ions and clusters in the amorphous-to-crystalline transformation process through dissolution-reprecipitation reactions [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite

et al. 2021

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Surface-mineralized collagen sponges have attracted much attention as scaffolds for bone tissue engineering. Recently, we developed amorphous calcium phosphate (ACP) and low-crystalline apatite coating processes on collagen sponges. In the present study, we applied these coating processes to granular collagen sponges (referred to as Col) to compare the bone tissue regeneration capabilities of ACP-coated and apatite-coated Col (referred to as Col-ACP and Col-Ap, respectively) using a rat cranial bone defect model. According to micro-CT and histological analyses, Col-Ap enhanced bone tissue regeneration compared to Col, whereas Col-ACP did not. These results not only demonstrated the superior bone tissue regeneration capability of Col-Ap, but also indicated limitations of the in vitro simulated body fluid (SBF) test used in our previous study. Despite the apatite-forming ability of Col-ACP in SBF, it was ineffective in improving bone tissue regeneration in vivo, unlike Col-Ap, most likely due to the quick resorption of the ACP coating in the defect site. The present results clarified the importance of the coating stability in vivo and revealed that the low-crystalline apatite coating was more beneficial than the ACP coating in the fabrication of surface-mineralized collagen sponges for use as bone tissue engineering scaffolds.

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“…20 The HA/Ti crystallinity was found to be high, while the amorphous phase, which is susceptible to rapid dissolution and degradation in a biological environment, was limited to 7.6%. 23,24 Thus, the potential for a reduction of both the coating-substrate bond strength and implant fixation, due to the disintegration of the coating, was significantly mitigated. 3,5,18 A high coating crystallinity is also critical for the attachment of bone forming cells in the initial healing phase; it also stimulates the proliferation and differentiation of osteoblast cells.…”

Section: Discussionmentioning

confidence: 99%