1987
DOI: 10.1002/jps.2600760909
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Dissolution Kinetics of Griseofulvin in Sodium Dodecylsulphate Solutions

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Cited by 25 publications
(12 citation statements)
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“…The difference in the 20-fold increase and the 6-fold increase observed between the solubility and dissolution is due to the contribution to the total transport of both the enhanced solubility from the micelle solubilization, a 20-fold increase, and the effective diffusivity of the micelle-solute complex, a 3-fold decrease, hence the net 6-fold enhancement in dissolution. [4][5][6][7][8][9][10][11] Regression analysis of the data in Figure 5 yielded an intercept of 2, which is statistically different from the theoretical intercept of 1 predicted by eq 15 (p < 0.01). A possible explanation for this deviation may be found in the model assumption of constant micelle size for all concentrations of surfactant.…”
Section: Resultsmentioning
confidence: 68%
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“…The difference in the 20-fold increase and the 6-fold increase observed between the solubility and dissolution is due to the contribution to the total transport of both the enhanced solubility from the micelle solubilization, a 20-fold increase, and the effective diffusivity of the micelle-solute complex, a 3-fold decrease, hence the net 6-fold enhancement in dissolution. [4][5][6][7][8][9][10][11] Regression analysis of the data in Figure 5 yielded an intercept of 2, which is statistically different from the theoretical intercept of 1 predicted by eq 15 (p < 0.01). A possible explanation for this deviation may be found in the model assumption of constant micelle size for all concentrations of surfactant.…”
Section: Resultsmentioning
confidence: 68%
“…approximated by the Levich equation (eq 9) is Equation 9 can be applied to micelle-facilitated dissolution by substituting D eff for D i and c total for c s(o) to give [6][7][8][9][10] The reaction factor, φ FM , which is the total flux divided by the flux of the free solute, is given by Equation 12 is based on the assumption that the diffusional boundary layer, as defined by the effective diffusivity, is the same for both the solute and the micelle. This is a reasonable approximation when the diffusivities of all species are similar.…”
Section: Theoretical Sectionmentioning
confidence: 99%
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“…Singh et al 6 investigated the influence of micelle-drug solubilization on the dissolution rate for the benzocainepolysorbate 80 system under different hydrodynamic models. De Smidt et al [7][8][9] reported the effect of sodium lauryl sulfate on the dissolution of griseofulvin, a poorly soluble drug. On the other hand, Mooney et al 10,11 investigated the effect of pH on the solubility and dissolution of ionizable drugs based on a film model with total component material balances for reactive species, proposed by Olander.…”
Section: Introductionmentioning
confidence: 98%