1972
DOI: 10.1002/jps.2600611207
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Dissolution of Alkyl Vinyl Ether-Maleic Anhydride Copolymers and Ester Derivatives

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Cited by 26 publications
(6 citation statements)
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“…The dissolution profile of the anhydride copolymer powder material correlated with reported dissolution studies of the polymer free acid film (14) and the compressed copolymer disk (12). In these studies, a similar lag time or induction period followed by an apparent zero-order dissolution process was observed.…”
Section: Scheme 111supporting
confidence: 74%
See 1 more Smart Citation
“…The dissolution profile of the anhydride copolymer powder material correlated with reported dissolution studies of the polymer free acid film (14) and the compressed copolymer disk (12). In these studies, a similar lag time or induction period followed by an apparent zero-order dissolution process was observed.…”
Section: Scheme 111supporting
confidence: 74%
“…1,125,000) of methyl vinyl ether and maleic anhydride (Scheme I) was prepared by completely dissolving the anhydride copolymer [assayed purity = 99.9% using potentiometric method (12)] in water to produce the totally hydrolyzed free acid, which was then lyophilized to a white dry powder. wt.…”
Section: ~ ~mentioning
confidence: 99%
“…T h e amount of gelatin combined with Gantrez decreased as the molecular weight of Gantrez increased from 250000 for G119 to 750000 for G149 (Woodruff et al 1972). T h e acid value determined experimentally for the two grades were identical, therefore, results obtained can be owed to coiled structure of G149 molecule with less exposed carboxylic groups for the reaction with the gelatin molecule.…”
Section: Colloid Combination Ratiomentioning
confidence: 49%
“…However, because of the progressive carboxyl ionization and ester hydrolysis under physiological conditions, the number of ionizable groups along the chain increases, affording a partially degraded structure, which becomes water soluble, thus enabling the classification of the system as bioerodible. The fraction of ionized carboxyl groups necessary for matrix solubilization and the pH at which ionization occurs depend on the hydrophilic/hydrophobic balance of both ether and ester residues [33][34][35]. Therefore, the release pattern from systems based on these polymers can be tuned easily by an appropriate structural balance of the two functionalities.…”
Section: Hemiesters Of Copolymers Of Maleic Anhydride and Alkyl Vinyl Ementioning
confidence: 99%