Dissolution of Fibers Inhaled by Rats

Models for Mesothelioma Incidence Following Exposure to Fibers in Terms of Timing and Duration of Exposure and the Biopersistence of the Fibers

“…The influence of overload declined with increasing length of fibers, and for fibers longer than 25 µm they concluded that the rate of disappearance was independent of lung burden, implying that the disappearance was probably due to dissolution. These results are in accord with those given by Eastes and Hadley (1995), who demonstrated that the elimination of fibers from rats' lungs after exposure by inhalation was in agreement with predictions based on the dissolution rate measured in vitro. Davis et al (1996) and Jones et al (1997) gave some preliminary results from the Colt Fibre Research Programme, which examined the effects of fiber characteristics, including durability, on toxicity.…”

The thermal transformation of Man Made Vitreous Fibers (MMVF) and safe recycling as secondary raw materials (SRM)

“…Instead, to this aim the concept of biopersistence has been introduced [12][13][14][15][16][17][18][19][20][21][22][23][24]. Both the European Community (EC) and the IARC have recognized the importance of biopersistence in fiber toxicology wherefore it has been incorporated in their classification schemes.…”

Biopersistence, Fiber Length, and Cancer Risk Assessment for Inhaled Fibers

“…The dissolution rate of a fiber, as determined by the rate constant K dis , is measured in in vitro flow experiments using a balanced salt solution (simulated lung fluid). Although investigators have shown some correlation between K dis and biopersistence (Eastes & Hadley, 1995), some researchers have objected to the use of K dis as a measure of biopersistence since there is considerable variation in the measurement of K dis among different laboratories (Zoitos et al, 1997). Furthermore, it has been pointed out that K dis measures solubility only and fails to take into account the fiber's tendency to fracture in the lung or tendency to be phagocytosed, which are other important components of biopersistence.…”