Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets

Hyun, Ja; Hong, Jun Kee; Lee, Sung Wan; Uk, Jae; Ko, Won Hwa; Baek, Hyon Ho; Park, Hyun Jin

doi:10.9721/kjfst.2012.44.3.274

Cited by 3 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the n value ranges from 0.45 to 0.89, it represents non-Fickian release (anomalous release), indicating that both the gel diffusion of the active ingredient and gel erosion occur appropriately during the release. When the value is greater than 0.89, it signifies super case II transport, indicating that the erosion of the gel dominates in the release mechanism [49]. Therefore, the release of vitamin C from HA-based ODFs was found to exhibit slightly different release mechanisms depending on the thickness.…”

Section: Applied Model Formula Analysismentioning

confidence: 96%

Influence of Casting Variables on Release Kinetics of Orally Disintegrating Film

Shin,

Han

2024

Foods

View full text Add to dashboard Cite

As a new form for supplying vitamin C, orally disintegrating films (ODFs) were developed C based on hyaluronic acid (HA) under varying casting conditions and the properties were analyzed. The films with different thicknesses (2, 3, and 8 mm, for CT2, CT4, and CT8, respectively) were produced by adjustments made to casting height. Two types of 8 mm thick ODFs produced by single or double casting (4 + 4 mm for CTD4+4) methods were also compared. As film thickness increased, water vapor permeability and tensile strength also increased. Even at equal thickness, manufacturing with double casting exhibited a stronger texture and reduced disintegration compared to single casting. All ODFs met the World Health Organization’s recommended daily vitamin C intake (45 mg/day) with a single sheet. Films showed over 80% dissolution in various solvents, adhering to the Hixson–Crowell cube root law, indicating vitamin C release occurred via porous penetration of the eluate. For CT2, CT4, and CTD4+4, vitamin C release was primarily governed by diffusion within the gel matrix and HA erosion. However, for CT8, HA erosion-induced release somewhat dominated. Based on the sensory test, it seems desirable to adjust the thickness of the film to 2 or 4 mm, because a thickness greater than that increased the foreign body sensation due to prolonged residence in the oral cavity.

show abstract

Section: Applied Model Formula Analysismentioning

confidence: 96%

Influence of Casting Variables on Release Kinetics of Orally Disintegrating Film

Shin,

Han

2024

Foods

View full text Add to dashboard Cite

show abstract

Preparation of quercetin and rutin-loaded ceramide liposomes and drug-releasing effect in liposome-in-hydrogel complex system

Park

Lee

Kim

et al. 2013

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Development of Porous Cellulose-Hydrogel System for Enhanced Transdermal Delivery of Quercetin and Rutin

Lee¹,

Kim²,

Park³

2013

Polymer Korea

View full text Add to dashboard Cite

In this study, the porous cellulose hydrogel as a carrier to enhance the skin delivery of quercetin and its glycoside, rutin known as flavonoid antioxidants was prepared and its properties were investigated. The optimum cellulose hydrogel for quercetin and rutin was made by the reaction of 2 wt% cellulose with 12% ECH. In the release test of the hydrogel containing the flavonoids, the release of quercetin was diffusion-controlled at 10~500 µM, but rutin was released by the erosion of hydrogel system at 10~50 µM. Both the encapsulation efficiency and release amount of rutin in hydrogel were higher than quercetin. However, in skin permeation experiment using Franz diffusion cell, quercetin showed higher skin permeation capacity than rutin. The hydrogel containing flavonoids showed remarkable transdermal permeation than the control group. These results suggest that porous cellulose hydrogel is potential drug delivery system to enhance transdermal permeation of water-insoluble flavonoid antioxidants.

show abstract

Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets

Cited by 3 publications

References 32 publications

Influence of Casting Variables on Release Kinetics of Orally Disintegrating Film

Influence of Casting Variables on Release Kinetics of Orally Disintegrating Film

Preparation of quercetin and rutin-loaded ceramide liposomes and drug-releasing effect in liposome-in-hydrogel complex system

Development of Porous Cellulose-Hydrogel System for Enhanced Transdermal Delivery of Quercetin and Rutin

Contact Info

Product

Resources

About