Dissolution profiles prediction of sinomenine hydrochloride sustained-release tablets using Raman mapping technique

Prediction of dissolution profiles of sinomenine hydrochloride sustained-release tablets part I: using near-infrared spectra as predictors

“…In general, if the value of f 1 is above 15 and the value of f 2 is below 50, the actual dissolution curve and the predicted dissolution curve are considered to be different. 29 Additionally, the prediction of the dissolution behavior in this batch of tablets is considered to have failed.…”

“…Despite advanced spectroscopy imaging technology, such as the Raman imaging technique, employed for predicting the dissolution profiles of OSDs, 28,29 larger areas are scanned in order to obtain much more information about multiple positions, so the test is time-consuming. In addition, the advantage of spectral imaging technology is the assessment of nonhomogeneity in a system, 30 whereas most OSDs are uniform in pharmaceutical manufacturing.…”