Dissolution Rate of Griseofulvin in Bile Salt Solutions

Dissolution of Ionizable Water‐Insoluble Drugs: The Combined Effect of pH and Surfactant

“…Singh et al 6 investigated the influence of micelle-drug solubilization on the dissolution rate for the benzocainepolysorbate 80 system under different hydrodynamic models. De Smidt et al [7][8][9] reported the effect of sodium lauryl sulfate on the dissolution of griseofulvin, a poorly soluble drug. On the other hand, Mooney et al 10,11 investigated the effect of pH on the solubility and dissolution of ionizable drugs based on a film model with total component material balances for reactive species, proposed by Olander.…”

Effect of Chitosan on Gastrointestinal Absorption of Water-Insoluble Drugs Following Oral Administration in Rats

“…13) There is an in vitro report indicating that the solubility and dissolution rate of griseofulvin increase with increasing the medium concentration of bile salts such as sodium taurocholate and sodium cholate. 31) Miyazaki et al 32) have reported that the enhancement of the dissolution of indomethacin in the presence of bile acids, including sodium desoxycholate, sodium cholate, sodium glycocholate and sodium taurocholate, is due mainly to micellar solubilization. Based on these observations, it is considered that the prolonged T max for indomethacin and griseofulvin in chitosan-pretreated rats may be caused by disruption in micelle formation due to the binding of bile acids to chitosan, leading to reduction of any solubilization effect by bile acids.…”

Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water‐soluble Drugs Solubilized in Model Lipid Digestion Products

“…Estimates of the activity coefficient obtained using the polymer partition method in simple NaTC micellar systems were compared with values of the free fraction obtained from micellar equilibrium solubility data available in the literature. [16][17][18] Figure 5A-C shows the data obtained for griseofulvin, diazepam, and danazol, respectively, from the two methods. Comparison of the two methods shows that the data obtained using the polymer partitioning method are very similar to that derived from micellar solubility data.…”