Dissolution Rates of Model Gallstones in Human and Animal Biles and Importance of Interfacial Resistance

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

“…Subsequent studies examined the dissolution of hydrocortisone in simple and mixed micellar systems and determined that wetting was the predominant factor that improved the rate of dissolution in simple bile salt micelles, whereas solubilization appeared to be major mechanism for improving dissolution in the mixed micellar systems. 59 The solubility and dissolution of cholesterol in bile salts has been extensively studied by Higuchi et al [73][74][75][76][77][78][79][80] Although these studies were targeted towards understanding gallstone dissolution, they provide valuable data regarding the dissolution of highly lipophilic compounds. Dissolution was facilitated by simple bile salt micelles, although addition of lecithin to form mixed micelles markedly decreased dissolution in spite of improved solubility.…”

Mesophase formation during cholesterol dissolution in ursodeoxycholate–lecithin solutions: New mechanism for gallstone dissolution in humans

“…only recently (9). Hormone release from such systems was investigated to obtain devices for longterm contraceptive purposes.…”

Invited commentary

“…There is no evidence that any organic additive would enhance the dissolution rate of a concentrated, hypertonic bile acid solution. Amphipathic cationic substances, such as benzalkonium chloride, markedly accelerate dissolution of cholesterol in cholate-lecithin solutions [16], but this enhancing effect is much less in animal bile samples, such as from the dog, which are very unsaturated and have relatively high bile acid-lecithin ratios [17].…”