Dissolution test of herbal medicines containing Passiflora sp.

Abstract

Abstract:The dissolution test is an essential tool to assess the quality of herbal medicines in the solid dosage form for oral use. This work aimed to evaluate the dissolution behavior of three herbal medicines in the form of capsules and tablet containing Passiflora, produced with powder or dried extract. Assay of total flavonoids and dissolution methods were validated and obtained results allowed the quantification of flavonoids with precision, accuracy and selectivity. The percentage of total flavonoids found was 2% for capsule A (containing only powder), 0.97% for capsule B (containing only dried extract) and 5.5% for tablet. Although the content was lower, the release of flavonoids present in the capsule containing dried extract was 12% higher over 30 min, with dissolved percentage values of 87 and 75, for the capsules containing extract and powder, respectively. The tablet containing dried extract presented dissolution of 76%, despite the higher content of flavonoids, which may be due to pharmacotechnical problems. Obtained data demonstrated the need to implement these tests in the quality control of herbal medicines, confirming the release of the active ingredients that underlie the pharmacological action of these medicines.

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“…Coated hawthorn extract tablets with acceptable disintegration time and dissolution has been produced. HPLC method for assessing the dissolution of herbal tablets has been recommended as against spectrophotometry since identifying the matrix used by manufacturers could prove impossible 26 . A RP-HPLC method which is simple, selective, accurate and reliable has been developed for assessing the in vitro dissolution of hawthorn extract tablet.…”

“…No disintegration within 30min 0.09 T 20 20.67±1.37 0.08 T 21 13.17±2.56 0.00 T 22 6.17±0.98 0.00 T 23 8.17±0.98 0.00 T 24 9.17±0.98 0.00 T 25 12.17±1.94 0.00 T 26 3.83±0.41 0.00 T 27 4.67±0.52 0.00 T 28 5.17±0.75 0.00 T 29 6.67±0.82 0.00 T 30 7…”

“…To maximize the opportunity and overcome challenges associated with herbal medicines, new technologies to modernize their preparations are being evaluated 24 and employing these new technologies and processes can ensure the efficacy and safety of herbal products 25 . Dissolution of herbal products may add to the innovative processes in the pharmaceutical industry 26 .…”

Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products

“…The dissolution test used in this study is classified as a category III procedure (i.e., analytical procedure for determination of performance characteristics); hence the need to evaluate its precision by repeatability (9). Six replicate samples, containing the SDAE 1 material, were collected from six vessels of the dissolution apparatus (at pH 1.2) at a 60-minute sampling time.…”

Quantificação de fenóis totais presentes nas cascas de Trichillia catigua A. Juss (Meliaceae)

“…Embora diversos estudos tenham demonstrado a necessidade de garantir segurança aos produtos de origem vegetal (Brandão et al, 2002;Choi et al, 2002;Bara et al, 2004;Bara et al, 2006), a validação de métodos analíticos para matérias-primas a base de plantas ainda é escassa na literatura (Wang et al, 2003;Ribani et., 2004;Rolim et al, 2005;Lima et al, 2006;Costa et al, 2011;Couto et al, 2011;Sousa et al, 2011;Oliveira et al, 2012). A validação de método analítico tem por objetivo demonstrar que o mesmo é apropriado para a finalidade pretendida, garantindo por meio de estudos experimentais o atendimento aos parâmetros de seletividade, linearidade, intervalo, precisão, limite de detecção, limite de quantificação, exatidão e robustez adequados às análises (Brasil, 2003).…”