Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

Chen, Huanhuan; Cheng, Yu‐Hao; Tian, Jingrun; Yang, Peizheng; Zhang, Xuerao; Chen, Yunhao; Hu, Yiqiao; Wu, Jinhui

doi:10.1126/sciadv.aba4311

Cited by 291 publications

(233 citation statements)

References 40 publications

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“…In the process of wound healing, new capillaries grow into the wound at an amazing speed and produce a large number of new vascular networks, whose density is 2, 3 or even 10 times of that of normal tissue [ 23 ]. Endothelial cells are essential cells for blood vessels and play an important role in vascularization [ 24 ]. The HUVECs migration and tube formation assays were conducted to assess the angiogenic activity of the hydrogels.…”

Section: Resultsmentioning

confidence: 99%

“…Due to the tough wound healing environment caused by diabetes, the complete and rapid healing of DFUs is challenging [ 32 ]. High glucose exposure interferes with the stability of hypoxia-inducible factor-1, leading to the failure of diabetic wound to up-regulate vascular endothelial growth factor (VEGF) in response to soft tissue ischemia, resulting in impaired angiogenesis [ 24 ]. Previous studies have shown that BG can release Si ions to promote angiogenesis [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

et al. 2021

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Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

et al. 2021

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“…However, current oxygen therapy approaches are unable to sustainedly provide sufficient oxygen to metabolic-demanding skin cells to promote diabetic wound healing (50)(51)(52)(53). In this work, we developed an oxygen-release system to continuously oxygenate the diabetic wounds.…”

Section: Discussionmentioning

confidence: 99%

Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation

Guan¹,

Huang²,

Z³

et al. 2021

Preprint

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Non-healing diabetic wound is one of the most common complications for diabetic patients. Chronic hypoxia is among the prominent factors that delay the wound healing process. Therefore, sustained oxygenation to alleviate hypoxia is hypothesized to promote diabetic wound healing. Yet it cannot be achieved by current clinical approaches including hyperbaric oxygen therapy. Herein, we developed a sustained oxygenation system consisting of oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel. The hydrogel was used to capture the ROS that is elevated in the diabetic wounds, and that may be generated due to oxygen release. The sustainedly released oxygen augmented survival and migration of keratinocytes and dermal fibroblasts; promoted angiogenic growth factor expression, and angiogenesis in the diabetic wounds; and decreased M1 macrophage density. These effects led to a significant increase of wound closure rate. These findings reveal that sustained oxygenation alone without using drugs is capable of healing diabetic wounds.

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“…The biostable and conductive PGCNSH can also deliver electrical stimulation in vivo, which brings about a synergetic therapeutic effect on chronic wounds. The diabetic wound, a typical chronic non-healing wound that significantly endangers patients' health, [53,54] was chosen as the model to investigate electrotherapy using the PGCNSH (Figure 5g; Figure S21, Supporting Information). By comparing the groups with and without electrical stimulation (ES), we found that wounds in ES groups exhibited faster wound closure (Figure 5h,i).…”

Section: Pgcnsh For Electrical-stimulated Therapy On Diabetic Woundmentioning

confidence: 99%

Conductive Cellulose Bio‐Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics

Yan

Zhou

Han

et al. 2021

Adv Funct Materials

101

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Biostable electronic materials that can maintain their super mechanical and conductive properties, even when exposed to biofluids, are the fundamental basis for designing reliable bioelectronic devices. Herein, cellulose-derived conductive 2D bio-nanosheets as electronic base materials are developed and assembled into a conductive hydrogel with ultra-high biostability, capable of surviving in harsh physiological environments. The bio-nanosheets are synthesized by guiding the in situ regeneration of cellulose crystal into a 2D planar structure using the polydopamine-reduced-graphene oxide as supporting templates. The nanosheet-assembled hydrogel exhibits stable electrical and mechanical performances after undergoing aqueous immersion and in vivo implantation. Thus, the hydrogel-based bioelectronic devices are able to conformally integrate with the human body and stably record electrophysiological signals. Owing to its tissue affinity, the hydrogel further serves as an "E-skin," which employs electrotherapy to aid in the faster healing of chronic wounds in diabetic mice through transcutaneous electrical stimulation. The nanosheet-assembled biostable, conductive, flexible, and cell/tissue affinitive hydrogel lays a foundation for designing electronically and mechanically reliable bioelectronic devices.

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Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

Cited by 291 publications

References 40 publications

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation

Conductive Cellulose Bio‐Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics

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