Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

Ling, Ming Hung; Chen, Mei-Chin

doi:10.1016/j.actbio.2013.06.029

Cited by 246 publications

(166 citation statements)

References 45 publications

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“…Microneedles offer four different approaches, all of which have been applied to peptides: 1) pretreatment with microneedles followed by application of the formulation Mohammed et al, 2014); 2) dissolving microneedles that release the peptide rapidly and simultaneously to the microneedle dissolution (Fukushima et al, 2011;Ling and Chen 2013); 3) coated microneedles releasing their peptide coating (Cormier et al, 2004;Tas et al, 2012); and 4) hollow microneedles enabling microinjections (Davis et al, 2005;Wang et al, 2006;Norman et al, 2013). When commercially available microneedle rollers were used as pretreatment to create micropores into rat skin followed by the application of insulin solution, the microneedles rollers could increase skin permeability for insulin-lowering blood glucose levels .…”

Section: A Development Challenges Of Peptide Delivery Formulationsmentioning

confidence: 99%

Novel Delivery Systems for Improving the Clinical Use of Peptides

et al. 2015

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Section: A Development Challenges Of Peptide Delivery Formulationsmentioning

confidence: 99%

Novel Delivery Systems for Improving the Clinical Use of Peptides

et al. 2015

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“…One such example for vaccines delivery is reported by Edmonston-Zagreb for measles vaccination (Nordquist et al, 2007;Herwadkar & Banga, 2012;Kis et al, 2012;Singh et al, 2012;Edens et al, 2013;Koutsonanos et al, 2013;Ling & Chen, 2013;Cai et al, 2014;Gill et al, 2014). Vaccinations have the capacity to be delivered using MN patches, which require the patient to have no specialized training or the need for cold/refrigerated storage; this in turn can reduce the spread of diseases Edens et al, 2013).…”

Section: Why Mns?mentioning

confidence: 99%

“…However, there are disadvantages associated with TDPs, for example, the prevention of large molecules from bypassing the SC, the outermost layer of the skin, which is the ratelimiting barrier (Sinha & Kaur, 2000;Garland et al, 2011;Han & Das, 2013;Ling & Chen, 2013). TDPs are applicable for molecules that are traditionally smaller than 500 Da (Benson, 2005).…”

Section: Dd Routesmentioning

confidence: 99%

“…Table 2 illustrates a general overview of the transdermal MN methods used to administer drugs and vaccines. For example, the table shows that dissolving insulinbased MNs were made with starch and gelatin (Ling & Chen, 2013) for a five-minute dissolution time when inserted into the skin. It was shown that 600 mm height and 300 mm base MN retained pharmacological activity in the starch/gelatin matrix.…”

Section: Solid Mnsmentioning

confidence: 99%

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Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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“…Mei-Chin Chen et al [38][39] investigated that drugs loaded in chitosan carriers can be released through swelling and degradation of the chitosan matrix, leading to a clear sustained-release effect. Chitosan with suitable molecular weight can be cleared by the kidney in vivo, whereas excessive molecules can be cleaved by proteases into fragments to be suitable for renal clearance.…”

Section: Macromolecular Drugsmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hong

Chen

et al. 2014

Nano-Micro Lett

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Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms. In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

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Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

Cited by 246 publications

References 45 publications

Novel Delivery Systems for Improving the Clinical Use of Peptides

Novel Delivery Systems for Improving the Clinical Use of Peptides

Microneedles for drug delivery: trends and progress

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

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