Distal esophageal wall thickness correlates with dysphagia in adult patients with eosinophilic esophagitis

Wong, Stephanie; Tippett, Marcus; Zobel, Joshua; Safaeian, Romina; Holloway, Richard H.; Ruszkiewicz, Andrew; Nguyen, Nam Q.

doi:10.1007/s10388-022-00924-7

Cited by 5 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the initial assessment study, patients between 18 and 70 years of age with a diagnosis of EoE (defined as ≥15 eosinophils/high powered field with symptoms of esophageal dysfunction and exclusion of other causes of esophageal eosinophilia) were retrieved from a pre‐existing database and enrolled at their outpatient clinic/endoscopy appointments or via an invitation letter 19 . Enrolled patients underwent an endoscopy with EUS and mucosal biopsies and completed a dysphagia score 19 . Esophageal wall thickness was measured in a contracted state to avoid distortion caused by longitudinal furrows and ensure constant distensibility of the esophagus 19 .…”

Section: Methodsmentioning

confidence: 99%

“…in a randomized placebo‐controlled trial of oral viscous budesonide in adult EoE patients was used in the study 20 . This score assessed the frequency (none [0] to several times per day [5]) and intensity of dysphagia (unhindered swallowing [0] to obstruction requiring endoscopic intervention [5]) with total scores ranging from 0 to 10 19 . These patients were then invited to return for a follow‐up endoscopy with EUS and mucosal biopsies along with completion of a dysphagia score ≥1 year after their initial assessment.…”

Section: Methodsmentioning

confidence: 99%

“…19 Enrolled patients underwent an endoscopy with EUS and mucosal biopsies and completed a dysphagia score. 19 Esophageal wall thickness was measured in a contracted state to avoid distortion caused by longitudinal furrows and ensure constant distensibility of the esophagus. 19 A non-validated, modified version of the dysphagia score used by Straumann et al in a randomized placebo-controlled trial of oral viscous budesonide in adult EoE patients was used in the study.…”

Section: Methodsmentioning

confidence: 99%

“…19 Esophageal wall thickness was measured in a contracted state to avoid distortion caused by longitudinal furrows and ensure constant distensibility of the esophagus. 19 A non-validated, modified version of the dysphagia score used by Straumann et al in a randomized placebo-controlled trial of oral viscous budesonide in adult EoE patients was used in the study. 20 This score assessed the frequency (none [0] to several times per day [5]) and intensity of dysphagia (unhindered swallowing [0] to obstruction requiring endoscopic intervention [5]) with total scores ranging from 0 to 10.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background and Aim: Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro-stenotic phenotype due to esophageal sub-epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of this study was to longitudinally assess the endoscopic appearance, wall thickness, histology, and dysphagia score of EoE patients. Methods: Patients with EoE were recruited and studied between February 2012 and April 2021. Patients were evaluated on two separate occasions at least 12 months apart with endoscopy, EUS, and esophageal mucosal biopsies. The dysphagia score and epidemiology data were also assessed. Results: A total of 16 EoE patients were included with a mean follow-up duration of 2.2 AE 1.2 years. In 14/16 (88%) patients, the total wall thickness of the distal esophagus significantly increased (P = 0.0012) as a result of thickening of the muscularis propria (P = 0.0218). However, only 1/14 (7%) patient had an increase in the dysphagia score, while 8/14 (57%) and 5/14 (36%) had a stable and reduced dysphagia score, respectively. No differences were found in the total thickness of other esophageal regions, dysphagia score, endoscopic appearance, and eosinophil count over time. Conclusion: Distal esophageal wall thickness increases with time in EoE patients, independent of the dysphagia score and eosinophil count.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis

Leech,

Peiris

2024

J Gastroenterol

View full text Add to dashboard Cite

Gastro-oesophageal reflux disease (GORD) is a chronic condition characterised by visceral pain in the distal oesophagus. The current first-line treatment for GORD is proton pump inhibitors (PPIs), however, PPIs are ineffective in a large cohort of patients and long-term use may have adverse effects. Emerging evidence suggests that nerve fibre number and location are likely to play interrelated roles in nociception in the oesophagus of GORD patients. Simultaneously, alterations in cells of the oesophageal mucosa, namely epithelial cells, mast cells, dendritic cells, and T lymphocytes, have been a focus of GORD research for several years. The oesophagus of GORD patients exhibits both macro- and micro-inflammation as a response to chronic acidic reflux at the epithelium. In other conditions of the GI tract, such as IBS and IBD, well-characterised bidirectional processes between immune cells and mucosal nerve fibres contribute to pathogenesis and symptom generation. Sensory alterations in these conditions such as nerve fibre outgrowth and hypersensitivity can be driven by inflammatory processes, which promote visceral pain signalling. This review will examine what is currently known of the molecular pathways linking inflammation and sensory perception leading to the development of GORD symptoms and explore potentially relevant mechanisms in other GI regions which may indicate new areas in GORD research.

show abstract

Epithelial-Fibroblast Crosstalk in Eosinophilic Esophagitis

Muir,

Karakasheva,

Whelan

2024

Cellular and Molecular Gastroenterology and Hepatology

View full text Add to dashboard Cite

Distal esophageal wall thickness correlates with dysphagia in adult patients with eosinophilic esophagitis

Cited by 5 publications

References 30 publications

Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis

Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis

Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis

Epithelial-Fibroblast Crosstalk in Eosinophilic Esophagitis

Contact Info

Product

Resources

About