“…Some investigators have reported significant improvements in tissue healing and bone formation using PRP [1,4,7,8,11,12,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] whereas others did not observe improvements [2,5,13,14,[32][33][34][35][36]. Some have given no conclusion regarding effect of PRP application in maxillofacial region than periodontal defects [37].…”