Distal sensory polyneuropathy among HIV-infected patients at Parakou University Hospital, Benin, 2011

Adoukonou, Thierry; Kouna-Ndouongo, Philomène; Kpangon, Arsène; Gnonlonfoun, Dieudonné; Kpacha, B.; Dovonou, Albert; Houinato, Dismand

doi:10.1684/mst.2017.0685

Cited by 6 publications

(4 citation statements)

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“…Motor symptoms described in the treated HIV population include slowing, clumsiness, poor balance, and loss of fine motor control (Fama et al, 2007 ; Robertson et al, 2007 ; Sullivan E. V. et al, 2011 ; Bernard et al, 2013 ; Wilson et al, 2013 ; Prakash et al, 2016 ). Peripheral neuropathy, a persisting and prevalent (15–40%, Newton, 1995 ; Evans et al, 2008 ) HIV-associated disturbance in the post-ART era (Geraci and Simpson, 2001 ; Robertson et al, 2011 ; Kranick and Nath, 2012 ; Gabbai et al, 2013 ), is also associated with older age (Saylor et al, 2017 ) and ART (Dragovic and Jevtovic, 2003 ; Venhoff et al, 2010 ; Birbal et al, 2016 ; Weldegebreal et al, 2016 ; Adoukonou et al, 2017 ; Benevides et al, 2017 ) and likely contributes to impaired motor control.…”

Section: Neuropsychological and Motor Effects Of Hiv And Comorbiditiementioning

confidence: 99%

The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity

Zahr

2018

Front. Aging Neurosci.

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As successfully treated individuals with Human Immunodeficiency Virus (HIV)-infected age, cognitive and health challenges of normal aging ensue, burdened by HIV, treatment side effects, and high prevalence comorbidities, notably, Alcohol Use Disorders (AUD) and Hepatitis C virus (HCV) infection. In 2013, people over 55 years old accounted for 26% of the estimated number of people living with HIV (~1.2 million). The aging brain is increasingly vulnerable to endogenous and exogenous insult which, coupled with HIV infection and comorbid risk factors, can lead to additive or synergistic effects on cognitive and motor function. This paper reviews the literature on neuropsychological and in vivo Magnetic Resonance Imaging (MRI) evaluation of the aging HIV brain, while also considering the effects of comorbidity for AUD and HCV.

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Section: Neuropsychological and Motor Effects Of Hiv And Comorbiditiementioning

confidence: 99%

The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity

Zahr

2018

Front. Aging Neurosci.

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“…In previous studies neurological disorders accounted for more than 50% [4]. We reported previously 42.4% of the prevalence of distal sensory polyneuropathy among the HIV outpatients in Parakou [5]. In Bobo-Dioulasso at Burkina Faso Millogo and al reported 14% of neurological disorders in HIV patients [6].…”

Section: Introductionmentioning

confidence: 95%

Neurological Disorders among the Outpatients Living with Human Immuno Deficiency Virus (HIV) Following at the Parakou Hospital in 2014

Thierry¹,

Mendinatou²,

Jolianelle³

et al. 2019

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Objective: To study the frequency of neurological disorders associated to HIV infection. Methods: This cross-sectional study was carried out from 16th June to 16th September 2014 and included all 289 HIV-outpatients admitted to the Parakou University hospital. All data were recorded, physical examination was performed and the medical sheet of each patient was assessed. The diagnosis of neurological disorder (central and peripheral) was based on clinical features, past medical history, biological test and CT-scan data after multidisciplinary staff. Epi-data and Epi-Info 6.04C were used to perform analysis. Results: They were 73 (25.3%) male with a mean age of 38.0 years +/− 10.1 years. The mean duration of disease was 48.5 months +/− 37.1 months. 150 (51.9%) of them were at Stage 3 of the disease. All patients (99.7%) were infected by HIV1, 188 (76.1%) had CD4 cells at the onset of the follow-up less than 350 cells/mm 3 and 260 (90.0%) were on ART. Among the 289 patients, 110 had at least one neurological disorder, the frequency of neurological disorders was 38.1%. The main neurological disorders were peripheral neuropathy (34.3%), isolated headache (5.2%), stroke (0.7%), cerebral toxoplasmosis (0.7%) and one case of dementia (0.7%). The main associated factors were the age of patient and exposure on neurotoxic drug, especially ART. Conclusion: The neurological disorders were more frequent among HIV patients with a high frequency of peripheral neuropathy probably due to ART.

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“…Evaluating pain syndrome in ambulatory AIDS patients, Hewitt et al reported a 28% incidence of pain due to polyneuropathy among participants [5] Another study conducted by Tagliati et al [6], found distal pain present in 38% among patients with distal polyneuropathy. In a more recent study, Adoukonou et al revealed the presence of pain in 23.4% of patients [7], while other studies report painful symptoms in up to 75% of HIV-SN participants [8]. Pain is associated with depression and poor quality of life [1,[9][10][11].…”

Section: Introductionmentioning

confidence: 97%

Pharmacologic and Non-Pharmacologic Interventions for HIV-Neuropathy Pain. A Systematic Review and a Meta-Analysis

et al. 2019

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Background and Objectives: Among HIV infection symptoms, sensory neuropathy (HIV-SN) remains a main cause of suffering, with incidence varying from 13–50%. So far, numerous pharmacological and non-pharmacological treatments have been tested, although few evidence-based analgesic options are available. We conducted an up-to-date systematic review and meta-analysis of the literature in order to evaluate the efficacy and safety of pharmacologic and non-pharmacologic treatments for pain control, in patients with HIV neuropathy. Materials and Methods: We searched MEDLINE, EMBASE, Scopus/Elsevier, The Cochrane Central Register of Controlled Trials (CENTRAL), USA Clinical Trials registry, and The International Web of Science up to April 2019. All randomized controlled trials evaluating efficacy and safety of non-pharmacologic and pharmacologic therapies were included. Efficacy was defined as pain reduction during the study period. Safety was estimated from adverse events. A meta-analysis was performed whenever possible. Results: 27 randomized controlled trials (RCTs) were included for analysis (7 evaluating non pharmacologic interventions, 20 pharmacologic therapies). Non-pharmacologic studies (n = 742) involved seven different therapeutic modalities. Only Acupuncture/Moxibustion showed pain reduction over placebo, Gracely Pain Scale Mean (SD): Acu/Moxa 0.85 (0.12), placebo 1.10 (0.09), p = 0.05. Pharmacologic studies, involving 2516 patients revealed efficacy for capsaicin 8% over placebo (mean difference −8.04 [95% CI: −14.92 −1.15], smoked cannabis (where pooling data for meta-analysis was not possible) and recombinant Nerve Growth Factor. Conclusion: Despite various modalities for pain control in HIV-SN, strongest evidence exists for capsaicin 8% and smoked cannabis, although of low methodological quality. Among non-pharmacologic modalities, only Acu/Moxa gave a marginal beneficial effect in one study, possibly limited by inherent methodological flaws.

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Distal sensory polyneuropathy among HIV-infected patients at Parakou University Hospital, Benin, 2011

Cited by 6 publications

References 0 publications

The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity

The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity

Neurological Disorders among the Outpatients Living with Human Immuno Deficiency Virus (HIV) Following at the Parakou Hospital in 2014

Pharmacologic and Non-Pharmacologic Interventions for HIV-Neuropathy Pain. A Systematic Review and a Meta-Analysis

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