Distal transformation from double-half forearms in the axolotl, Ambystoma mexicanum

Krasner, Gary N.; Bryant, Susan V.

doi:10.1016/0012-1606(80)90433-9

Cited by 32 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no effect of healing time on either double anterior or double posterior zeugopodia. Krasner and Bryant (1980) also did not detect any effect of healing time on double posterior zeugopodia of adult newt limbs. In a more detailed study of the effect of healing time on somewhat larger axolotl larvae, regenerative capacity of double posterior stylopodia decreased rapidly to near zero from 5 to 30 days of healing time (Tank & Holder, 1978), whereas amputating the constructs at the same time they were made resulted in the regeneration of symmetrical double posterior limbs (Holder et al., 1980).…”

Section: Pattern Formation In the Blastemamentioning

confidence: 92%

“…Amputated double anterior stylopodia regenerate only a symmetrical tapered cone of cartilage, whereas double posterior stylopodia regenerate double posterior limbs with a symmetrical distal stylopodium, two ulnae or fibulae and six (forelimb) to eight (hindlimb) digits, with some fusion of structure in the midline (Bryant, 1976; Bryant & Baca, 1978; Holder, Tank, & Bryant, 1980; Krasner & Bryant, 1980; Stocum, 1978; Tank, 1979). Double dorsal and double ventral stylopodia regenerate double dorsal and double ventral limbs, respectively, including symmetrical muscle patterns (Burton, Holder, & Jesani, 1986; Ludolph, Cameron, & Stocum, 1990).…”

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

“…Double dorsal and double ventral stylopodia regenerate double dorsal and double ventral limbs, respectively, including symmetrical muscle patterns (Burton, Holder, & Jesani, 1986; Ludolph, Cameron, & Stocum, 1990). Double anterior zeugopodia regenerate two radii or tibias that converge distally, one to two carpals or tarsals and a single symmetrical digit, in contrast to double posterior zeugopodia which regenerate a double ulna or fibula and two symmetrical sets of posterior digits (Bryant & Baca, 1978; Holder et al., 1980; Krasner & Bryant, 1980; Stocum, 1978). …”

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

View full text Add to dashboard Cite

This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization. (5) Models of pattern formation based on the results of axial reversal experiments, experiments on the regeneration of half and double half limbs, and experiments using retinoic acid to alter positional identity of blastema cells. (6) Possible mechanisms of distalization during normal and intercalary regeneration. (7) Is pattern formation is a self‐organizing property of the blastema or dictated by chemical signals from adjacent tissues? (8) What is the future for regenerating a human limb?

show abstract

Section: Pattern Formation In the Blastemamentioning

confidence: 92%

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

View full text Add to dashboard Cite

show abstract

“…However, a double half anterior stylopodium regenerated only a symmetrical spike of cartilage, whereas a double half posterior stylopodium regenerated symmetrical double posterior zeugopodia and autopodia with up to six digits, suggesting an inequality of positional information in these halves of the stylopodium (Bryant, 1976;Stocum, 1978;Maden, 1979a;Holder et al, 1980;Krasner and Bryant, 1980;Wigmore and Holder, 1985). Subsequently, double half limb experiments showed that double dorsal stylopodia regenerate PD-complete symmetrical limbs, whereas double ventral stylopodia fail to regenerate (Ludolph et al, 1990).…”

Section: Models Of Pattern Formationmentioning

confidence: 99%

Looking proximally and distally: 100 years of limb regeneration and beyond

Stocum

Cameron

2011

Developmental Dynamics

108

View full text Add to dashboard Cite

The experimental study of amphibian limb regeneration spans most of the 20 th century and the first decade of the 21 st century. We first review the major questions investigated over this time span: (1) the origin of regeneration blastema cells, the mechanism of tissue breakdown that liberates cells from their tissue organization to participate in blastema formation, (3) the mechanism of dedifferentiation of these cells, (4) how the blastema grows, (5) how the blastema is patterned to restore the missing limb structures, and (6) why adult anurans, birds and mammals do not have the regenerative powers of urodele salamanders. We then look forward in a perspective to discuss the many unanswered questions raised by investigations of the past century, what new approaches can be taken to answer them, and what the prospects are for translation of basic research on limb regeneration into clinical means to regenerate human appendages. Developmental Dynamics 240:943-968,

show abstract

“…Midline-derived cells of grafts from control anterior half zeugopodia would be expected to interact with anterior cells of the host limb to form a double anterior regenerate (for examples of double anterior zeugopodial regenerates, see Stocum, 1978;Krasner and Bryant, 1980). In addition, a supernumerary regenerate is predicted to arise on the posterior side of the host limb, where anterior cells of the graft are confronted with posterior cells of the host (Fig.…”

Section: Graftsmentioning

confidence: 99%