Background
The clinical management of intermittent exotropia has been discussed
extensively in the literature, yet there remains a lack of clarity regarding
indications for intervention, the most effective form of treatment and
whether or not there is an optimal time in the evolution of the disease at
which any treatment should be carried out.
Objectives
The objective of this review was to analyse the effects of various
surgical and non-surgical treatments in randomised trials of participants
with intermittent exotropia, and to report intervention criteria and
determine the significance of factors such as age with respect to
outcome.
Search methods
We searched the Cochrane Central Register of Controlled Trials
(CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials
Register) (The Cochrane Library, Issue 4, 2012), MEDLINE
(January 1966 to May 2012), EMBASE (January 1980 to May 2012), Latin
American and Caribbean Literature on Health Sciences (LILACS) (January 1982
to May 2012), the metaRegister of Controlled Trials
(mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical
Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or
language restrictions in the electronic searches for trials. We last
searched the electronic databases on 4 May 2012. We are no longer searching
the UK Clinical Trials Gateway (UKCTG) for this review. We manually searched
the British Orthoptic Journal up to 2002, and the proceedings of the
European Strabismological Association (ESA), International Strabismological
Association (ISA) and American Academy of Paediatric Ophthalmology and
Strabismus meeting (AAPOS) up to 2001. We contacted researchers who are
active in the field for information about further published or unpublished
studies.
Selection criteria
We included randomised controlled trials of any surgical or
non-surgical treatment for intermittent exotropia.
Data collection and analysis
Each review author independently assessed study abstracts identified
from the electronic and manual searches. Author analysis was then compared
and full papers for appropriate studies were obtained.
Main results
We found one randomised trial that was eligible for inclusion. This
trial showed that unilateral surgery was more effective than bilateral
surgery for correcting the basic type of intermittent exotropia.
Authors’ conclusions
The available literature consists mainly of retrospective case
reviews, which are difficult to reliably interpret and analyse. The one
randomised trial included found unilateral surgery more effective than
bilateral surgery for basic intermittent exotropia. However, across all
identified studies, measures of severity and thus criteria for intervention
are poorly validated, and there appear to be no reliable natural history
data. There is therefore a pressing need for improved measures of severity,
a better understanding of the natural history and carefully planned clinical
trials of treatment to improve the e...