Distant metastases from carcinoma of the larynx

Abramson, Allan L.; Parisier, Simon C.; Zamansky, Marshall J.; Sulka, Michael

doi:10.1288/00005537-197109000-00015

Cited by 42 publications

(17 citation statements)

References 7 publications

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“…Distant spreading is rare and is sustained by hematogenous dissemination or perineural invasion. [ 6 ] The incidence of clinical distant metastases from laryngeal SCC ranges from 1% to 4%[ 1 ] and the lung is the most frequent site, followed by bone and liver. [ 4 ] Intracranial metastases from laryngeal SCC are extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] Differently from this wide group of tumors, distant metastases from SCC originating exclusively in the larynx are less frequent with a reported incidence less than 4% of cases. [ 1 ] Moreover, to our knowledge, only few cases of intracranial metastases from laryngeal SCC have been reported in the literature. [ 2 4 5 10 12 13 14 15 16 ] As a result, it is difficult to collect a wide series of brain metastasis form laryngeal SCC to give indications about the prognosis and the treatment of this condition.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors in brain metastases from laryngeal squamous cell carcinoma: Case report and review

Montano¹,

Rapisarda²,

Pignotti³

et al. 2018

Surg Neurol Int

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Background:Brain metastases from laryngeal squamous cell carcinoma (SCC) are rare, and there are no standardized treatments. Here we reported on a case of brain metastasis from laryngeal SCC and performed a literature review on these cases. Moreover, by plotting Kaplan–Meier curves, we carried out a survival analysis to provide an estimation of overall survival (OS) and to find possible prognostic factors.Case Description:A 65-year-old male was admitted to our department with a large left occipital lesion. Three years ago, the patient had undergone total laryngectomy with bilateral neck dissection with a diagnosis of a poor differentiated SCC. The occipital lesion was totally removed. A diagnosis of a brain metastasis from laryngeal SCC was made. The patient was submitted to adjuvant chemotherapy and radiation therapy. He is in good clinical conditions at 7-month follow-up with a still ongoing chemotherapy. From survival analysis, we have found that surgery and/or radiochemotherapy increase the OS of these patients compared with untreated cases. Moreover, Karnofsky performance status (KPS) score ≥70 and recursive partitioning analysis (RPA) classes I and II were associated with better OS in these patients.Conclusion:Brain metastases from laryngeal SCC are rare. This is the first study in which a survival analysis of these cases has been performed. Surgery and/or radio-chemotherapy increase the survival of these patients compared with untreated cases. Moreover, KPS score and RPA class affect the outcome of these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic factors in brain metastases from laryngeal squamous cell carcinoma: Case report and review

Montano¹,

Rapisarda²,

Pignotti³

et al. 2018

Surg Neurol Int

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“…The overall incidence of clinically detected distant metastasis in head and neck squamous cancers is 9-11% [3]. Distant metastasis in laryngeal cancers are reported to range from 1-4% [4]. Among the laryngeal tumors, supraglottic tumors have the highest incidence of distant metastasis owing to rich lymphatic and vascular supply.…”

Section: Discussionmentioning

confidence: 99%

Isolated intracranial metastasis from an early glottic cancer: how rare a presentation?

Bakshi

Verma

Chakraborty

et al. 2009

Indian J Otolaryngol Head Neck Surg

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The incidence of distant metastasis with laryngeal tumors varies from 1-4% [1]. The lungs are the most frequent site, followed by bone and liver. Intracranial metastases are rarely clinically diagnosed in head neck cancer patients and if present are mainly located in the cerebrum and cerebellum. Early stage glottic squamous carcinoma with subsequent distant metastasis is rare [2]. We report a patient with T1N0 glottic tumor who underwent a curative radiotherapy and on 3 months follow up presented with isolated intracranial metastasis.

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“…The most common site of metastasis in HNC and LSCC is lung [7][8][9] . In a retrospective analysis of 1022 patients with HNC, 110 patients had lung metastases, accounting for 78% of all distant metastases [2] .…”

Section: Introductionmentioning

confidence: 99%

Risk factors and survival outcomes of laryngeal squamous cell carcinoma patients with lung metastasis: A population-based study

et al. 2021

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Distant metastases from carcinoma of the larynx

Cited by 42 publications

References 7 publications

Prognostic factors in brain metastases from laryngeal squamous cell carcinoma: Case report and review

Prognostic factors in brain metastases from laryngeal squamous cell carcinoma: Case report and review

Isolated intracranial metastasis from an early glottic cancer: how rare a presentation?

Risk factors and survival outcomes of laryngeal squamous cell carcinoma patients with lung metastasis: A population-based study

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