Distant Metastases from Nasopharyngeal Cancer

Chiesa, Fausto; Paoli, F. De

doi:10.1159/000055743

Cited by 72 publications

(40 citation statements)

References 7 publications

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“…As the majority of nonkeratinizing NPC patients (89.3% in the current study) are N-positive at presentation and the presence of distant metastases is strongly associated with the N stage (10), a substantial proportion of patients are expected to have distant metastases. At primary staging, overt distant metastases have been detected in up to 11% of patients by means of conventional studies, whereas subclinical metastases that remained initially undetected may become apparent shortly thereafter (12,13). In a study by Micheau et al, about 40% of nonkeratinizing NPC patients with advanced N-stage disease (N2 or N3) had tumor invasion in the bone marrow as demonstrated by transiliac biopsy (14).…”

Section: Discussionmentioning

confidence: 99%

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Liu¹,

Lin²,

Chang³

et al. 2007

Journal of Nuclear Medicine

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Conventional work-up (CWU) with chest radiography, abdominal ultrasonography, and skeletal scintigraphy has limited value in M staging of nonkeratinizing nasopharyngeal carcinoma (NPC). Our aim was to evaluate whether 18 F-FDG PET could replace CWU by comparing their diagnostic efficacies. Methods: Patients with histologically proven nonkeratinizing NPC and no prior treatment were prospectively enrolled. All study participants underwent CWU and 18 F-FDG PET for primary M staging. Distant metastasis was considered to be present if there was any reliable evidence identified within 1 y after diagnosis. The comparative diagnostic efficacies of 18 F-FDG PET, CWU, and the combination of 18 F-FDG PET and CWU (PET1CWU) were evaluated using the areas under the receiver-operating-characteristic (ROC) curves. Results: Sixty-one (20.3%) of 300 eligible patients were found to have distant metastases. On a patient-based analysis, 18 F-FDG PET was found to be more effective than CWU (P , 0.001), whereas it was equally effective with PET1CWU (P 5 0.130). On region-based analyses, 18 F-FDG PET was more effective than skeletal scintigraphy and chest radiography for detecting bone metastases (P , 0.001) and chest metastases (P , 0.001), respectively. 18 F-FDG PET and abdominal ultrasound were equally effective for detecting hepatic metastases (P 5 0.127). On region-based analyses, the combination of 18 F-FDG PET and CWU did not yield any noticeable increase in diagnostic efficacy. Conclusion: 18 F-FDG PET can replace CWU in primary M staging of nonkeratinizing NPC.

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Section: Discussionmentioning

confidence: 99%

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Liu¹,

Lin²,

Chang³

et al. 2007

Journal of Nuclear Medicine

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“…The biological characteristics and abundant peripheral lymphoid tissue involvement of NPC make this malignancy more prone to metastasis and invasion compared with other head and neck tumors. Partial recurrence and distant metastasis of NPC are causes of treatment failure (7). Consequently, the majority of patients succumb to the effects of tumor metastasis rather than to the primary lesion.…”

Section: Introductionmentioning

confidence: 99%

Effects of silencing S100A8 and S100A9 with small interfering RNA on the migration of CNE1 nasopharyngeal carcinoma cells

et al. 2015

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Abstract. The calcium-binding S100 proteins are involved in functions such as cell growth, differentiation, migration, adhesion and signal transduction. S100A8 and S100A9 are highly expressed in a variety of tumor cells, and are implicated in tumor development and progression. However, the role of S100A8 and S100A9 in nasopharyngeal carcinoma (NPC) cell migration is unclear. The present study investigated the effect of S100A8 and S100A9 on migration using a NPC cell line, CNE1. The CNE1 cells were transfected with S100A8 or S100A9 small interfering RNA (siRNA). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect S100A8 and S100A9 gene expression. Following the downregulation of S100A8 or S100A9, the effects on cell migration were determined using wound-healing assays. The expression of matrix metalloproteinase-7 (MMP7), a member of the MMP family that is associated with tumor cell invasion and migration, was also detected by RT-qPCR. S100A8 and S100A9 siRNAs effectively suppressed S100A8 and S100A9 gene expression, and substantially inhibited the migration of the CNE1 cells. In addition, MMP7 expression was reduced to varying extents in S100A8 and S100A9 siRNA-treated cells compared with controls. Thus, S100A8 and S100A9 promoted the migration of CNE1 NPC cells.

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“…The numbers of these cases are too few. However, NPC is closely related to Epstein-Barr virus (EBV), peculiar natural history and a good prognosis [11] and OPC is also closely related with Human papilloma virus (HPV) 16 [12]. Indeed, in our two cases of NPC, EBV and also in our three cases of OPC, HPV 16 were proven.…”

Section: Discussionmentioning

confidence: 54%

Bone metastases from head & neck squamous cell carcinoma (HNSCC) – Reviewing the patients’ background and imaging features mainly of whole body MRI (WBMRI)

Nakanishi¹,

Sakai²,

Sumikawa³

et al. 2017

Cancer Rep Rev

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The aim of this article is to review images of bone metastases from Head & Neck Squamous Cell Carcinoma (HNSCC) mainly of whole body MRI (WB-MRI). 14 cases of HNSCC were reviewed (2, nasopharynx; 3, oropharynx; 2, hypopharynx; 4, tongue; 2, larynx; 1, nasal cavity). In four of these 14 cases, only bone metastases have been found more than 14 months. In all cases, the metastatic lesions were seen as high intensity on diffusion-weighted images (DWI) on MRI. In five of our 14 cases, osteosclerotic patterns were recognized in CT. In these five, two were nasopharyngeal carcinoma (NPC) and the other three were oropharyngeal carcinoma (OPC). In two cases of NPC, Epstein-Barr virus (EBV) and in three cases of OPC, Human papilloma virus (HPV) 16 were proven. In the other four cases, neither osteosclerotic nor lytic patterns were shown. Hence, they were classified as intertrabecular patterns. In the other five cases, osteolytic patterns were recognized along with the lesions. Bone metastases from HNSCC are rare but need to be detected. It is often found with lung or liver metastases, but it can appear alone. Although, on CT bone metastases could appear in various patterns, these lesions appear consistently as high intensity on DWI of MRI.

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Distant Metastases from Nasopharyngeal Cancer

Cited by 72 publications

References 7 publications

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Effects of silencing S100A8 and S100A9 with small interfering RNA on the migration of CNE1 nasopharyngeal carcinoma cells

Bone metastases from head & neck squamous cell carcinoma (HNSCC) – Reviewing the patients’ background and imaging features mainly of whole body MRI (WBMRI)

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