Distant metastases in differentiated thyroid carcinomas: A clinical and pathologic study

Mizukami, Yuji; Michigishi, Takatoshi; Nonomura, Akitaka; Hashimoto, Takuma; Terahata, Shintaro; Noguchi, Masakuni; Hisada, Kinichi; Matsubara, Fujitsugu

doi:10.1016/0046-8177(90)90228-w

Cited by 89 publications

(62 citation statements)

References 19 publications

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“…However, in four serous pleural fluid samples, the primary cancer could not be identified due to degeneration; in these samples, thyroglobulin titer was used to confirm the diagnosis of MPE from DTC. During the lifetime of patients with DTC, 6.6% to 9% developed distant metastasis [8,9]. The overall mortality rates at 5 years and 10 years after diagnosis of metastases were 65% and 75%, respectively.…”

Section: Discussionmentioning

confidence: 91%

“…Until recently, there was no effective systemic therapy for DTC patients with MPE; in fact, most MPE patients with DTC were reported to have iodine-resistant disease. Mizukami et al reported that the 10-year survival rate of patients with metastases that lacked I-131 uptake was significantly poorer than that of patients with metastases with good uptake [9]. As a novel therapeutic strategy, targeted therapy has been proven to be useful for advanced or metastatic I-131-refractory thyroid cancer, especially for pulmonary metastases.…”

Section: Discussionmentioning

confidence: 99%

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Outcome and characteristics of patients with malignant pleural effusion from differentiated thyroid carcinoma

et al. 2016

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Outcome and characteristics of patients with malignant pleural effusion from differentiated thyroid carcinoma

et al. 2016

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“…Although PTC is more common than FTC, FTC is more prone to spread hematogenously, especially to the lungs and bone. 24) The metastatic lesion is usually hypervascular and osteolytic on radiological examination. 14) Bleeding is often profuse during surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Skull Base Metastasis From Follicular Thyroid Carcinoma -Two Case Reports-

Matsuno

Katakami

Okazaki

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 58-year-old woman and a 71-year-old woman presented with extremely rare skull base metastases from follicular thyroid carcinoma (FTC). Surgical removal and external radiotherapy were performed followed by iodine-131 ( 131 I) brachytherapy and thyroid hormone administration. The metastatic tumors in the skull base were well controlled. Treatment for skull base metastasis from FTC includes surgical debulking of the metastatic lesion, as well as complete resection of the thyroid gland, followed by internal irradiation with 131 I, external irradiation, and administration of thyroid hormone to prevent tumor growth by suppression of endogenous thyroid-stimulating hormone. Skull base metastases may be the initial clinical presentation of FTC, with silent primary sites. The possibility of skull base metastasis from FTC should be considered in patients with clinical symptoms of cranial nerve dysfunction and radiological findings of bone destruction.

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“…The presence of distant metastases, however, significantly lowers this life expectancy. 23,24 The lungs and bones are the most common sites of metastatic disease, accounting for 53% and 20% of the cases of metastasis, respectively, with multiorgan involvement occurring in 16% of patients.3 Metastases to the spine are found in up to 68% of patients with thyroid cancer and are associated with a poor clinical outcome. 1,6,8,9,29 Only 1%-3% of patients with thyroid cancer have distant metastases at the time of initial diagnosis, but 7%-23% of patients will develop distant metastases over time.…”

mentioning

confidence: 99%

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confidence: 99%

Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

Sellin

Suki

Harsh

et al. 2015

SPI

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OBJECT Spinal metastases account for the majority of bone metastases from thyroid cancer. The objective of the current study was to analyze a series of consecutive patients undergoing spinal surgery for thyroid cancer metastases in order to identify factors that influence overall survival. METHODS The authors retrospectively reviewed the records of all patients who underwent surgery for spinal metastases from thyroid cancer between 1993 and 2010 at the University of Texas MD Anderson Cancer Center. RESULTS Forty-three patients met the study criteria. Median overall survival was 15.4 months (95% CI 2.8–27.9 months) based on the Kaplan-Meier method. The median follow-up duration for the 4 patients who were alive at the end of the study was 39.4 months (range 1.7–62.6 months). On the multivariate Cox analysis, progressive systemic disease at spine surgery and postoperative complications were associated with worse overall survival (HR 8.98 [95% CI 3.46–23.30], p < 0.001; and HR 2.86 [95% CI 1.30–6.31], p = 0.009, respectively). Additionally, preoperative neurological deficit was significantly associated with worse overall survival on the multivariate analysis (HR 3.01 [95% CI 1.34–6.79], p = 0.008). Conversely, preoperative embolization was significantly associated with improved overall survival on the multivariate analysis (HR 0.43 [95% CI 0.20–0.94], p = 0.04). Preoperative embolization and longer posterior construct length were significantly associated with fewer and greater complications, respectively, on the univariate analysis (OR 0.24 [95% CI 0.06–0.93] p = 0.04; and OR 1.24 [95% CI 1.02–1.52], p = 0.03), but not the multivariate analysis. CONCLUSIONS Progressive systemic disease, postoperative complications, and preoperative neurological deficits were significantly associated with worse overall survival, while preoperative spinal embolization was associated with improved overall survival. These factors should be taken into consideration when considering such patients for surgery. Preoperative embolization and posterior construct length significantly influenced the incidence of postoperative complications only on the univariate analysis.

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Distant metastases in differentiated thyroid carcinomas: A clinical and pathologic study

Cited by 89 publications

References 19 publications

Outcome and characteristics of patients with malignant pleural effusion from differentiated thyroid carcinoma

Outcome and characteristics of patients with malignant pleural effusion from differentiated thyroid carcinoma

Skull Base Metastasis From Follicular Thyroid Carcinoma -Two Case Reports-

Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

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