Distant metastases in epidermoid cell carcinoma of the head and neck

O’Brien, Paul H.; Carlson, Rodney F.; Steubner, Erwin A.; Staley, Charles T.

doi:10.1002/1097-0142(197102)27:2<304::aid-cncr2820270209>3.0.co;2-1

Cited by 111 publications

(27 citation statements)

References 6 publications

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“…The most common organ of distant metastasis of oral SCC was lung and this tendency corresponded to other reports 1,[3][4][5][6][7][8][9][10] .…”

Section: Discussionsupporting

confidence: 88%

“…In the present study, metastasis was examined clinically and histopathologically in patients with oral cancer in order to elucidate the factors involved in the mechanism of metastasis. The metastatic rate was reported to be from 7.5 to 57% in patients with oral SCC [3][4][5][6][7][8] . Metastasis was detected in 11.9% as a whole in this study, which was lower than the results reported by other authors.…”

Section: Discussionmentioning

confidence: 99%

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An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

Yasui¹,

Okada²,

Mataga³

et al. 2010

J. Hard Tissue Biology.

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Metastases to distant organs are well known to be factors influencing prognosis in patients with oral cancer. Therefore, it is very important to detect the metastasis of cancer as early as possible and to investigate the factors associated with the mechanism of metastasis. This study evaluated the risk of distant metastasis by the degree of histological malignancy among 59 patients with oral squamous cell carcinoma (SCC) who were treated at our department during the past five years. The degree of histological malignancy of initial biopsy specimens was evaluated by Anneroth's classification and its relationship with metastasis was analyzed. Distant metastasis occurred in 7 of 59 patients (11.9%) and was located predominantly in the lung and bone. There was a significant correlation between the degree of histological malignancy and distant metastasis (P<0.05); however, there was no significant difference between T classification and metastasis in the distant organs. It is considered that histological malignancy is useful for predicting the prognosis and deciding additional treatments for oral SCC. When a total score on histological malignancy grading exceeds 14, metastasis in the distant organs should be carefully considered.

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“…The most common organ of distant metastasis of oral SCC was lung and this tendency corresponded to other reports 1,[3][4][5][6][7][8][9][10] .…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

Yasui¹,

Okada²,

Mataga³

et al. 2010

J. Hard Tissue Biology.

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“…Compared with other head and neck tumours, nasopharyngeal carcinoma has a higher incidence of distant metastases (O'Brien et al, 1971;Probert et al, 1974;Merino et al, 1977). Based on clinical information without autopsy, 14.9-40.5% of distant metastases have been reported for nasopharyngeal carcinoma (Perez et al, 1969;Thompson et al, 1970;Moench et al, 1972;Hoppe et al, 1976;Bedwinek et al, 1980;Mesic et al, 1981), compared with 5.3-23.6% reported for other head and neck cancers (Castigliano et al, 1954;Arons et al, 1961;Hoye et al, 1962;Rubenfeld et al, 1962;Berger & Fletcher, 1971;Probert et al, 1974;Merino et al, 1977).…”

mentioning

confidence: 99%

Nasopharyngeal carcinoma: pattern of skeletal metastases

Sham¹,

Cheung²,

Chan³

et al. 1990

The British Journal of Radiology

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The records of 153 nasopharyngeal carcinoma patients with skeletal metastases were reviewed. The skeletal system was the most common site of distant metastases. The patients who developed skeletal metastases were significantly younger than those without skeletal metastases, although there was no difference between sexes. The pattern of skeletal involvement conforms to the general pattern, the spine and pelvis being the common sites. The first region of involvement was lumbar spine (28.4%), then dorsal spine (27.7%), sacrum and pelvis (16.3%), femur (9.9%), rib and sternum (7.8%), humerus (5.0%), cervical spine (3.5%) and skull vault (1.4%). Radiologically, the lesions were lytic in 66.0%, mixed lytic and sclerotic in 12.8% and sclerotic in 21.2%. The time to development of symptomatic skeletal metastases of mixed or sclerotic nature was significantly longer than lytic lesions, and patients with mixed or sclerotic metastases also had better survival.

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“…Distant metastasis is rare in life, but necropsy studies have shown a high incidence of micro-metastases outside the head and neck 8. As many as one in six patients have synchronous or metachronous carcinomas at other sites in the pharynx or tracheobronchial tree 9…”

mentioning

confidence: 99%

Improving the poor prognosis of oral squamous cell carcinoma

Hutchison¹

1994

BMJ

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Distant metastases in epidermoid cell carcinoma of the head and neck

Cited by 111 publications

References 6 publications

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

Nasopharyngeal carcinoma: pattern of skeletal metastases

Improving the poor prognosis of oral squamous cell carcinoma

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