Distant metastases in head and neck carcinoma: Identification of prognostic groups with MR imaging

Ljumanović, Redina; Langendijk, Johannes A.; Hoekstra, Otto S.; Leemans, C. René; Castelijns, Jonas A.

doi:10.1016/j.ejrad.2006.05.019

Cited by 59 publications

(35 citation statements)

References 21 publications

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“…We also report that nodal status was important to patient outcome whereas this relationship was not significant in the pimonidazole study. Our findings of an association between nodal involvement and poor patient outcome supports the reports in the literature that nodal status is the most important predictor of outcome in HNSCC 43,44 .…”

Section: Discussionsupporting

confidence: 82%

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Evans¹,

Du²,

Chalian³

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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Purpose-EF5, a 2-nitroimidazole hypoxia marker, was used to study the presence, levels and prognostic significance of hypoxia in primary head and neck squamous cell tumors.Methods and Materials-22 patients with newly diagnosed squamous cell carcinoma of the oral cavity, oropharynx or larynx with at least 2 years of clinical follow-up were included in this study. Quantitative analysis of EF5 immunofluorescence was carried out and these data were compared to patient outcome.Results-EF5 immunostaining demonstrated substantial inter-tumoral hypoxic heterogeneity. The majority of cells in all tumors were well oxygenated. Three patterns of EF5 binding in cells were identified using criteria of the cellular region that was stained (peripheral or central) and the relationship of binding to necrosis. We tested the association between EF5 binding levels with eventfree and overall survival, irrespective of the pattern of cellular binding or treatment regime. Patients with tumors containing EF5 binding regions corresponding to severe hypoxia (≤0.1% oxygen) had a shorter event-free survival time than patients with pO 2 values >0.1% (p=0.032). Nodal status was also predictive for outcome.Conclusions-These data illustrate the potential utility of EF5 binding based on quantitative immunohistochemistry of tissue pO 2 and provide support for development of noninvasive hypoxia PET studies with 18 F-EF5.

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Section: Discussionsupporting

confidence: 82%

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Evans¹,

Du²,

Chalian³

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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“…30,31 Risk factors include clinically palpable neck lymph nodes, histological evidence of nodal metastasis and extracapsular spread. [30][31][32] The lung is the most common site, representing 66% of haematogeneous metastases. 31 Differential diagnosis between lung metastasis from SCC and synchronous primary SCC is not easy (Figure 7).…”

Section: Scc Stagingmentioning

confidence: 99%

Computerised tomography and magnetic resonance imaging of laryngeal squamous cell carcinoma: A practical approach

et al. 2017

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“…Ljumanovic et al [24] identified prognostic groups with MR imaging for the development of distant metastases. The low-risk group consisted of patients without MRI-positive nodes, the intermediate-risk group consisted of patients with MRI-positive nodes without signs of extranodal spread and the high-risk group consisted of patients with MRIpositive nodes with signs of extranodal spread.…”

Section: Variablementioning

confidence: 99%

Pretreatment screening on distant metastases and head and neck cancer patients: Validation of risk factors and influence on survival

et al. 2015

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Distant metastases in head and neck carcinoma: Identification of prognostic groups with MR imaging

Cited by 59 publications

References 21 publications

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Computerised tomography and magnetic resonance imaging of laryngeal squamous cell carcinoma: A practical approach

Pretreatment screening on distant metastases and head and neck cancer patients: Validation of risk factors and influence on survival

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